Cu(bta)(1,10-phen)ClO4 copper complex modulates the carcinogenicity of carboplatin in somatic cells of Drosophila melanogaster
Paula Marynella Alves Pereira Lima,
Priscila Capelari Orsonlin,
Nayane Moreira Machado
et al.
Abstract:Chemotherapy stands out as the main systemic treatment strategy against cancer
and still faces problems related to multidrug resistance and severe side
effects. Copper-based drugs have been widely explored in medicinal chemistry,
since copper is an essential metal for physiological activities with
antineoplastic effects. In this context, the present study aimed to evaluate the
recombinogenic/mutagenic and anticarcinogenic potential of the complex CBP-01 -
[Cu(bta)(1,10-phen)ClO
4
] (Hbta… Show more
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