CTX-M-3<i>β</i>-Lactamase-Producing<i>Escherichia coli</i>from Greece

Mavroidi, Angeliki; Tzelepi, E.; Miriagou, Vivì; Gianneli, D.; Legakis, Nicholas J.; Tzouvelekis, L. S.

doi:10.1089/10766290252913737

Cited by 16 publications

(8 citation statements)

References 7 publications

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“…A lower rate (2%) of CTX-M-3 UTI was detected in community-acquired isolates at a French tertiary hospital and (7%) in a Greece tertiary care hospital, although a higher detection rate (28%) was reported in 24 Taiwan hospitals over a 2-year duration. [42][43][44] In conclusion, the present study documents the emerging threat of the high prevalence of ESβL Enterobacteriaceae in hospital-and community-acquired UTIs among Egyptian patients. Unfortunately, most of the drugs, such as fluoroquinolones and sulfamethoxazole, are not totally effective for empirical treatment of UTI.…”

Section: Discussionsupporting

confidence: 58%

Molecular Characterization of Extended-Spectrum β-Lactamase Enterobacteriaceae Isolated from Egyptian Patients with Community- and Hospital-Acquired Urinary Tract Infection

Shash

Elshimy

Soliman

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Extended-spectrum β-lactamases (ESβLs) pose a serious problem in the treatment of urinary tract infections (UTIs). The ESβL-producing organism is an expanding global health problem. Therefore, screening for ESβL, detection of their drug-resistance pattern, and molecular characterization should be a continuous process. The present study was performed to determine the antibiotic resistance profile and the genetic characterization of ESβL isolates from hospital-and community-acquired UTIs. Two hundred fifty Enterobacteriaceae isolates were obtained from urine samples of outpatient clinic attendants and hospitalized patients at Kasr Al-Aini Hospital. By phenotypic screening tests, 100 ESβL isolates were detected among the studied groups. Furthermore, detection of beta-lactamase (bla) cefotaxime (CTX)-M, sulfhydryl variable, and temoneira ESβL genes was investigated by polymerase chain reaction. A subset of 25 CTX-M-positive isolates was further identified by gene sequencing technology. Among the 100 ESβL isolates, 66% were Escherichia coli and 34% were Klebsiella spp. There was no statistical difference in the prevalence of ESβL Enterobacteriaceae in community-acquired versus hospital-acquired UTIs. The susceptibility of all ESβL isolates to carbapenems was the most prevalent finding. In addition, all ESβL E. coli isolates were susceptible to fosfomycin, whereas all community-acquired ESβL isolates were susceptible to nitrofurantoin. A total of 98% of the ESβL isolates harbored bla-CTX-M genes, with CTX-M-15 being the most prevalent. It could be concluded that ESβL production is present at a high rate among Egyptian patients with hospital-and community-acquired UTI. The high prevalence of bla-CTX-M may suggest it as a candidate for molecular screening of ESβL.

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Section: Discussionsupporting

confidence: 58%

Molecular Characterization of Extended-Spectrum β-Lactamase Enterobacteriaceae Isolated from Egyptian Patients with Community- and Hospital-Acquired Urinary Tract Infection

Shash

Elshimy

Soliman

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…A possible epidemiological link with the Latvian outbreak has not been investigated. CTX-M-3-producing E. coli strains unrelated to those reported in Poland were also isolated in Greece (59).…”

Section: Epidemiological Aspectsmentioning

confidence: 82%

Growing Group of Extended-Spectrum β-Lactamases: the CTX-M Enzymes

Bonnet

2004

Antimicrob Agents Chemother

1,309

1,084

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“…of the dissemination of CTX-M-1 and CTX-M-3 enzymes among E. coli isolates [8,9]. This is the first report of CTX-M-15 and CTX-M-33 in Greek isolates, underlining the growing diversity of CTX-M enzymes.…”

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confidence: 67%