CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4 pathway

Cai, Songhua; Zhang, Baohui; Huang, Chujian; Deng, Youjun; Wang, Chunguang; Yang, Yikun; Xiang, Zichang; Ni, Yao; Wang, Zhe; Wang, Lixu; Zhang, Baihua; Guo, Xiaotong; He, Jie; Ma, Kai; Yu, Zhentao

doi:10.1016/j.canlet.2023.216465

Cited by 2 publications

(1 citation statement)

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“…Recent studies highlight that lipid hydroperoxide dependent on glutathione peroxidase 4 (GPX4) has the potential to use glutathione (GSH) as a cofactor for the conversion of lipid peroxides in non-toxic lipid alcohols, thus protecting cells from lipid peroxidation. Therefore, inhibition of GPX4 is capable of inducing the development of ferroptosis [214][215][216].…”

Section: Ferroptosis and Organokinesmentioning

confidence: 99%

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

De Cól,

de Lima,

Pompeu

et al. 2024

IJMS

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Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and fatty liver dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, and metabolic syndrome are frequently present; these conditions are related to liver lipogenesis and systemic inflammation. This study aimed to review the connection between the brain–gut–liver axis and MAFLD. The inflammatory process, cellular alterations in hepatocytes and stellate cells, hypercaloric diet, and sedentarism aggravate the prognosis of patients with MAFLD. Thus, to understand the modulation of the physiopathology of MAFLD, it is necessary to include the organokines involved in this process (adipokines, myokines, osteokines, and hepatokines) and their clinical relevance to project future perspectives of this condition and bring to light new possibilities in therapeutic approaches. Adipokines are responsible for the activation of distinct cellular signaling in different tissues, such as insulin and pro-inflammatory cytokines, which is important for balancing substances to avoid MAFLD and its progression. Myokines improve the quantity and quality of adipose tissues, contributing to avoiding the development of MAFLD. Finally, hepatokines are decisive in improving or not improving the progression of this disease through the regulation of pro-inflammatory and anti-inflammatory organokines.

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Section: Ferroptosis and Organokinesmentioning

confidence: 99%