CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1

Tan, Wei-Hua; Peng, Zhengliang; You, Ting; Sun, Zhilu

doi:10.1007/s13105-022-00885-6

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…In this context, overexpressed ABCA1 in endothelial cells (ECs) has anti-inflammatory effects and increases cholesterol efflux [ 23 ]. Moreover, the different underlying mechanisms of ABCA1 and atherosclerosis have been illustrated in many studies [ 185 , 186 ]. Annexin A1 ( ANXA1 ) interacts with ABCA1 to exert its anti-atherogenic function [ 187 ].…”

Section: Abca1 and Cardiovascular Diseasesmentioning

confidence: 99%

Role of ABCA1 in Cardiovascular Disease

Wang

Xiao

Wang

et al. 2022

JPM

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Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA1 mediates nascent high-density lipoprotein biogenesis. Upon binding with apolipoprotein A-I, ABCA1 facilitates the efflux of excess intracellular cholesterol and phospholipids and controls the rate-limiting step of reverse cholesterol transport. In addition, ABCA1 interacts with the apolipoprotein receptor and suppresses inflammation through a series of signaling pathways. Thus, ABCA1 may prevent cardiovascular disease by inhibiting inflammation and maintaining lipid homeostasis. Several studies have indicated that post-transcriptional modifications play a critical role in the regulation of ABCA1 transportation and plasma membrane localization, which affects its biological function. Meanwhile, carriers of the loss-of-function ABCA1 gene are often accompanied by decreased expression of ABCA1 and an increased risk of cardiovascular diseases. We summarized the ABCA1 transcription regulation mechanism, mutations, post-translational modifications, and their roles in the development of dyslipidemia, atherosclerosis, ischemia/reperfusion, myocardial infarction, and coronary heart disease.

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Section: Abca1 and Cardiovascular Diseasesmentioning

confidence: 99%

Role of ABCA1 in Cardiovascular Disease

Wang

Xiao

Wang

et al. 2022

JPM

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“…CTRP15, also known as myonectin, is primarily derived from skeletal muscle and coordinates the integration of whole-body metabolism [ 9 ]. CTRP15 enhances reverse cholesterol transport efficiency and increases plasma HDL-C levels via the T-cadherin/miR-101-3p/ABCA1 pathway [ 10 ]. Increased CTRP15 expression has been observed in the adipose tissue of obese mice, while aerobic exercise has been reported to elevate circulating CTRP15 levels [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Combined serum CTRP7 and CTRP15 levels as a novel biomarker for insulin resistance and type 2 diabetes mellitus

Xue,

Ling,

Tian

et al. 2024

Heliyon

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Role of serum C1q/TNF-related protein family levels in patients with acute coronary syndrome

Liu

Wei

Ding

et al. 2022

Front. Cardiovasc. Med.

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BackgroundThe C1q/TNF-related protein (CTRP) family affects inflammation regulation, energy metabolism, and insulin signaling. However, their role in acute coronary syndrome (ACS) development is unclear. In this cross-sectional study, we aimed to investigate the association between CTRP family and ACS.MethodsWe enrolled 289 consecutive inpatients with suspected ACS. Serum CTRP family, tumor necrosis factor-α (TNF-α), and adiponectin (ADP) levels were assessed using enzyme-linked immunosorbent assay (ELISA). Multivariate logistic regression and subgroup analyses were used to assess risk factors for ACS. Spearman's tests were used to analyze correlations between CTRP family and continuous variables.ResultsSerum CTRP family levels differed significantly between ACS and Control groups (p < 0.05). After adjusting for confounding factors, CTRP family were independently associated with ACS (p < 0.05). The association between serum CTRP family levels and ACS was stable in various subgroups according to sex, age, diabetes mellitus, and dyslipidemia status (p for interaction > 0.05). Increasing tertiles of serum CTRP1 levels, significantly increased ACS risks, which decreased gradually with increasing CTRP2, CTRP12, and CTRP13 tertiles (p for trend < 0.05). Additionally, serum CTRP1, CTRP2, CTRP13, and CTRP15 levels were weakly correlated with the severity of coronary artery stenosis.ConclusionCTRP1 and CTRP5 were identified as independent ACS risk factors, whereas CTRP2, CTRP3, CTRP9, CTRP12, CTRP13, and CTRP15 were independent protective factors for ACS. CTRP family, especially CTRP1 and CTRP3 could be novel potential clinical biomarkers of ACS.

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CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1

Cited by 5 publications

References 37 publications

Role of ABCA1 in Cardiovascular Disease

Role of ABCA1 in Cardiovascular Disease

Combined serum CTRP7 and CTRP15 levels as a novel biomarker for insulin resistance and type 2 diabetes mellitus

Role of serum C1q/TNF-related protein family levels in patients with acute coronary syndrome

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