2010
DOI: 10.1074/jbc.m110.116020
|View full text |Cite
|
Sign up to set email alerts
|

CtpA, a Copper-translocating P-type ATPase Involved in the Biogenesis of Multiple Copper-requiring Enzymes

Abstract: The ctpA (ccoI) gene product, a putative inner membrane copper-translocating P1B-type ATPase present in many bacteria, has been shown to be involved only in the cbb 3 assembly in Rhodobacter capsulatus and Bradyrhizobium japonicum. ctpA was disrupted in Rubrivivax gelatinosus, and the mutants showed a drastic decrease in both cbb 3 and caa 3 oxidase activities. Inactivation of ctpA results also in a decrease in the amount of the nitrous oxide reductase, NosZ. This pleiotropic phenotype could be partially rescu… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

5
64
0
1

Year Published

2010
2010
2018
2018

Publication Types

Select...
5
3
2

Relationship

0
10

Authors

Journals

citations
Cited by 57 publications
(72 citation statements)
references
References 33 publications
5
64
0
1
Order By: Relevance
“….CXMXM motif beginning at residue 49 and ending at residue 99 (25). Thus, this protein is consistent with previously described copper export proteins in organisms like Escherichia coli, Bacillus subtilis, and Rhodobacter capsulatus (37)(38)(39)(40).…”
Section: Resultssupporting
confidence: 76%
“….CXMXM motif beginning at residue 49 and ending at residue 99 (25). Thus, this protein is consistent with previously described copper export proteins in organisms like Escherichia coli, Bacillus subtilis, and Rhodobacter capsulatus (37)(38)(39)(40).…”
Section: Resultssupporting
confidence: 76%
“…Contrary to this observation, disruption of Rubrivivax gelatinosus ctpA, a gene encoding a copper-translocating P1B-type ATPase, showed a drastic decrease in both cbb 3 and caa 3 oxidase activities but no copper-sensitive phenotype was obtained. This result indicated that R. gelatinosus the CtpA has a role in cytochrome oxidase assembly but is not essential for copper resistance [28]. These findings suggest that M.…”
Section: ) Bioinformatic Analyses and Protein Topology Of Copa Protesupporting
confidence: 60%
“…These include multiple copies of genes encoding either the copper-binding protein CusF (P1_123, P1_130, and P1_167) or a CtpA-like copper-transporting P-type ATPase (P1_50, P1_55, P1_120, and P1_121). This transporter is known to supply copper to membrane-associated proteins that require this metal as a cofactor (20). The presence of copper transport genes in the plasmid is interesting, as several enzymes, including the primary metabolic enzyme (pMMO), are copper dependent (29).…”
Section: Resultsmentioning
confidence: 99%