CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions
Cristina Herrera-Pariente,
Laia Bonjoch,
Jenifer Muñoz
et al.
Abstract:Background
CDH1 and CTNNA1 remain as the main genes for hereditary gastric cancer. However, they only explain a small fraction of gastric cancer cases with suspected inherited basis. In this study, we aimed to identify new hereditary genes for early-onset gastric cancer patients (EOGC; < 50 years old).
Methods
After germline exome sequencing in 20 EOGC patients and replication of relevant findings by gene-panel sequencing in an independent cohort of 152… Show more
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