CTNI-49. PHASE 1 STUDY OF ST101, a FIRST-IN-CLASS PEPTIDE ANTAGONIST OF CCAAT/ENHANCER-BINDING PROTEIN SS, IN PATIENTS WITH ADVANCED SOLID TUMORS, WITH a PHASE 2 EXPANSION IN RECURRENT GLIOBLASTOMA MULTIFORME
Abstract:BACKGROUND
C/EBPβ is a transcription factor that is active during embryofetal development but held in an inactive state in most mature cells (Zahnow 2009). C/EBPβ is upregulated or overactivated in multiple cancers, where it inversely correlates with disease prognosis and survival due to activation of a gene signature that promotes tumor cell proliferation and survival. ST101 is a cell-penetrating peptide antagonist of C/EBPβ. ST101 exposure leads to selective tumor cell death in multiple hum… Show more
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