CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with −318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients

Duan, Shaoqiong; Zhang, Guoyu; Han, Qunying; Zhu, Li; Liu, Zhengwen; Chen, Jinghong; Lv, Yi; Li, Na; Wang, Yawen; Li, Man; Lou, Sai; Yang, Mingbo; Zhu, Qianqian; Xing, Fanfan

doi:10.1007/s11033-010-0660-7

Cited by 31 publications

(42 citation statements)

References 41 publications

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“…[16][17][18][19] However, few reports are available about the relation between CTLA-4 polymorphisms and susceptibility to viral infection after HSCT. In our previous studies, a significant association was found between CTLA-4 -1661 A/G and -318 C/T genotypes and CMV and hepatitis B virus infection, respectively, after HSCT.…”

Section: Discussionmentioning

confidence: 99%

Association Between Cytotoxic T-Lymphocyte Antigen 4 Gene Polymorphisms and Torque Teno Virus Infection After Hematopoietic Stem Cell Transplantation

Ramzi¹,

Saadi²,

Tahereh³

et al. 2021

Exp Clin Transplant

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Objectives: An association between costimulatory molecule gene polymorphisms and viral infection after hematopoietic stem cell transplantation may be related to clinical outcomes, especially acute graftversus-host disease. Cytotoxic T-lymphocyte antigen 4 has been suggested as a crucial negative regulator of the immune system. In this study, our objective was to investigate the association between cytotoxic T-lymphocyte antigen-4 gene polymorphisms (including -1722 T/C, -1661 A/G, -318 C/T, and +49 A/G) and torque teno virus infection after hematopoietic stem cell transplantation in patients with and without acute graft-versus-host disease. Materials and Methods: Our study included 71 recipients. We evaluated cytotoxic T-lymphocyte antigen 4 gene polymorphisms using the polymerase chain reactionrestriction fragment length polymorphism method. Results: Our results showed that the GG genotype of the cytotoxic T-lymphocyte antigen 4 +49 A/G was significantly more frequent in transplanted patients infected with torque teno virus, whereas the AG genotype was more common in transplanted patients who did not have this infection. In addition, the -1661 AA and GA genotypes and -318 TC genotypes were significantly more frequent in transplanted patients infected with the virus and who had low-grade (grades I and II) acute graft-versus-host disease. Among those with grade I graft-versus-host disease, the GG genotype of the cytotoxic T-lymphocyte antigen 4+49 A/G was more frequent in transplanted patients with torque teno virus infection, whereas the AG genotype was higher in transplanted patients who did not have this infection.Conclusions: This is the first report indicating that cytotoxic T-lymphocyte antigen 4 gene polymorphism may be implicated in prevalence of torque teno virus infection after stem cell transplant. Further larger studies and evaluation of other costimulatory molecules are suggested. Key words: Graft-versus-host disease, Single nucleotide polymorphisms, Stem cell transplantation, Viral infections Introduction Transfusion-transmitted viruses or TT viruses, classified into the family Circoviridae, genusAnellovirus, were originally isolated in 1997 from the serum of a Japanese patient with posttransfusion hepatitis of unknown cause. Torque teno virus (TTV) is a nonenveloped, circular, and single-stranded DNA virus with genome of negative polarity. 1,2 Torque teno virus infection is common among hepatitis patients and is presented worldwide in blood donors. Because TTV sequences can be detected in sera and liver tissues from patients with liver disease, it has been suggested that TTV would be responsible for some acute and chronic liver disorders and thereby many autoimmune diseases such as idiopathic hepatitis, idiopathic pulmonary fibrosis, aplastic anemia, systemic lupus erythematosus, and multiple sclerosis. However, the biologic nature of TTV has not yet been clearly defined. [3][4][5] The costimulatory molecules, including programmed cell death-1 (PD-1), cluster differentiation 28 (CD28), indu...

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Section: Discussionmentioning

confidence: 99%

Association Between Cytotoxic T-Lymphocyte Antigen 4 Gene Polymorphisms and Torque Teno Virus Infection After Hematopoietic Stem Cell Transplantation

Ramzi¹,

Saadi²,

Tahereh³

et al. 2021

Exp Clin Transplant

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“…All the participants were of Chinese Han nationality and genetically unrelated. Of the 244 patients with chronic HBV infection, 120 patients were diagnosed with chronic hepatitis, 65 patients were diagnosed with liver cirrhosis, and 59 patients were diagnosed with HCC as had been described previously (Bruix and Sherman, 2005;Sorrell et al, 2009;Duan et al, 2011). The 76 subjects were classified as HBV infection resolvers based on the spontaneous recovery from HBV infection with serum negativity for HBsAg, HBeAg, and anti-HBe and positivity for anti-HBs and anti-HBc IgG.…”

Section: Study Subjectsmentioning

confidence: 99%

Association of Genetic Variation of Sodium Taurocholate Cotransporting Polypeptide with Chronic Hepatitis B Virus Infection

Zhang

Yang

et al. 2014

Genetic Testing and Molecular Biomarkers

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Background: Sodium taurocholate cotransporting polypeptide (NTCP) plays an important role in the enterohepatic circulation of bile acids and hepatocyte function and was recently proposed to be a functional receptor for hepatitis B virus (HBV). Objective: This study investigated the association of the functional polymorphism c.800C > T (p.S267F) (rs2296651) of the NTCP gene with HBV infection. Methods: The study included 244 patients with chronic HBV infection, 76 HBV infection resolvers, and 113 healthy controls. The polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The distribution of the genotype and allele frequency of rs2296651 polymorphism was significantly different among the HBV patients, HBV infection resolvers, and healthy controls ( p = 0.034 and p = 0.039, respectively). The frequency of genotype CT in HBV patients was significantly higher than that in healthy controls (11.9% vs. 4.4%, p = 0.026, odds ratios [OR] = 2.913, 95% confidence intervals [95% CI] = 1.097-7.738). The frequency of allele T in HBV patients was also significantly higher than that in healthy controls (5.9% vs. 2.2%, p = 0.029, OR = 2.793, 95% CI = 1.067-7.312). The frequency of genotype CT and allele T in HBV patients was higher than that in HBV infection resolvers although the difference was not significant. The genotype and allele frequency between infection resolvers and healthy controls and between HBV patients with different clinical diseases had no significant difference. Conclusion: These findings suggest that the rs2296651 polymorphism may predispose the susceptibility to and chronicity of HBV infection.

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“…The AA genotype and A allele of the CTLA-4 49A/G, and the genotype CC of the CTLA-4 -318 C/T polymorphisms was seen more frequently in chronic HBV-infected patients. 2 Thio Abbreviations: CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism *Considered significant with P value of .05. In genotypes, each P value is the result of comparing the corresponding row with the sum of the other rows.…”

Section: Discussionmentioning

confidence: 99%

“…Inefficiency of the host immune responses has been associated with the chronic and complicated HBV infection. 1,2 Immunologic genetic factors have played a role in altering the immune response and particularly, the outcome of HBV infection. 1,3 Therefore, understanding single nucleotide polymorphisms (SNPs) of several immunoregulatory genes (ie, costimulatory molecules) may be crucial for developing effective strategies against HBV.…”

Section: Introductionmentioning

confidence: 99%

“…8 Cytotoxic T-lymphocyte antigen-4 gene polymorphisms, which may affect the function of CTLA4 in regulating the immune response, has been proposed to affect the susceptibility and chronicity of the disease in patients with HBV infection; however, the results are still controversial. [9][10][11][12]2 Similar to CTLA4, CD28 also binds to B7 family of receptors (CD80 and CD86), but it provides a positive costimulatory signal for T-cell proliferative response after being expressed on T cells. 13,14 Several polymorphisms in the CD28 gene may affect the intensity of T-cell-mediated immunity, resulting in various autoimmune diseases, and the occurrence of post transplant allograft rejection.…”

Section: Introductionmentioning

confidence: 99%

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Yaghobi

Saadi²,

Karimi³

et al. 2014

Exp Clin Transplant

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CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with −318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients

Cited by 31 publications

References 41 publications

Association Between Cytotoxic T-Lymphocyte Antigen 4 Gene Polymorphisms and Torque Teno Virus Infection After Hematopoietic Stem Cell Transplantation

Association Between Cytotoxic T-Lymphocyte Antigen 4 Gene Polymorphisms and Torque Teno Virus Infection After Hematopoietic Stem Cell Transplantation

Association of Genetic Variation of Sodium Taurocholate Cotransporting Polypeptide with Chronic Hepatitis B Virus Infection

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