CTLA-4 +49A/G gene polymorphism and type 1 diabetes mellitus in the Chinese population: a meta-analysis of 2238 subjects

Abstract

Previous studies reported that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) +49A/G gene polymorphism is correlated with type 1 diabetes mellitus (T1DM) risk. However, their results remain disputable. This study aims to discuss the relationship between CTLA-4 +49A/ G gene polymorphism and T1DM in a Chinese population. The current meta-analysis involved 2238 participants from seven individual studies. The pooled odds ratio (OR) and its corresponding 95 % confidence interval (95 % CI) were assessed by the random-or fixed-effects model. A significant relationship between CTLA-4 +49A/G gene polymorphism and T1DM was detected under allelic (OR: 1.84, 95 % CI: 1.62-2.10, P<0.00001), dominant (OR: 1.152, 95 % CI: 1.062-1.249, P=0.001), recessive (OR: 1.631, 95 % CI: 1.443-1.844, P<0.00001), and additive (OR: 1.292, 95 % CI: 1.224-1.363, P<0.00001) genetic models. A significant relationship exists between CTLA-4

Juxtaposition of Coeliac Disease and Type 1 Diabetes; the Role of Shared Non-Human Leukocyte Antigen Loci

“…46,47 Multiple studies have noted predisposing role for minor G allele of this polymorphism for CD 18 and T1D. [13][14][15][19][20][21][22][23][24] Two studies; Mora et al, Naluai et al 16,17 have observed the higher risk of CD in individuals bearing the wild-type A allele of this polymorphism. On the other hand, some have not reported any significant association between this polymorphism with the occurrence of CD 12,13 and T1D.…”

Screening of potential biomarkers in the occurrence and development of type 1 diabetes mellitus based on transcriptome analysis

“…At present, the cause of T1DM is still unknown, and genetic susceptibility, a diabetogenic trigger, and high exposure to an antigen are believed to be involved [4]. A meta-analysis involving 2238 T1DM participants showed that individuals had a higher risk for T1DM with the G allele of CTLA-4 +49A/G gene polymorphism [5]. Arroyo-Jousse et al [6] found that T1DM patients showed a higher TNFa gene promoter methylation compared with control subjects [p=0.00008].…”