2007
DOI: 10.1016/j.vaccine.2006.12.038
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CTL epitopes for influenza A including the H5N1 bird flu; genome-, pathogen-, and HLA-wide screening

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Cited by 95 publications
(93 citation statements)
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“…Given the numerous examples of memory T cells that recognize conserved internal proteins, like NP, PA, M2, and basic polymerase (PB)1 (14,44) and given our data showing that Abs to one or more of these conserved proteins can facilitate T cell recall responses to these proteins, it makes sense to design vaccines that elicit memory T cells and high titers of Abs to these proteins. However, most influenza vaccines are composed of fixed whole virus, split virus, or purified HA and NA subunits (45).…”
Section: Discussionmentioning
confidence: 99%
“…Given the numerous examples of memory T cells that recognize conserved internal proteins, like NP, PA, M2, and basic polymerase (PB)1 (14,44) and given our data showing that Abs to one or more of these conserved proteins can facilitate T cell recall responses to these proteins, it makes sense to design vaccines that elicit memory T cells and high titers of Abs to these proteins. However, most influenza vaccines are composed of fixed whole virus, split virus, or purified HA and NA subunits (45).…”
Section: Discussionmentioning
confidence: 99%
“… CLIP-Seq/HITS-CLIP CLIP-Seq/HITS-CLIP merupakan kombinasi UV crosslinking dan imunopresipitasi dengan highthroughput sequencing untuk mengidentifikasi binding sites dari RNA-binding proteins, seperti: LIN28A, Argonaute (Ago), and Puf5p (Wang et al, 2007;Leung et al, 2011;Cho et al, 2012). Teknik OMICs tersebut umumnya diikuti oleh analisis data proteomik.…”
Section: Aplikasi Omics DI Biologi Sel Puncaunclassified
“…This method is widely used [9][10][11][12] and has been applied in a number of studies to identify potential vaccine targets [13,14]. The use of theoretical methods to ''pre-screen'' peptides is of particular importance in the case of emerging infections such as avian influenza [15] where rapid vaccine development would be vital. This approach underpins a large biopreparedness initiative coordinated by the Large-Scale Antibody and T Cell Epitope Discovery Program [7], which intends to foster development of immune-based therapeutics for emerging and reemerging pathogens including potential bioterrorism agents.…”
Section: Introductionmentioning
confidence: 99%