CTHRC1 modulates cell proliferation and invasion in hepatocellular carcinoma by DNA methylation
Xiangjun Sun,
Ye Liu,
Changdong Cheng
et al.
Abstract:Background
Collagen triple helix repeat containing-1 (CTHRC1), an extracellular matrix protein, is highly expressed in hepatocellular carcinoma (HCC) and linked to poor prognosis. Nevertheless, the precise mechanism of CTHRC1 in HCC is unclear.
Methods
Agena MassARRAY® Methylation Analysis assessed the methylation level of CTHRC1 in the promoter region. Functional assays were conducted to investigate the effects of CTHRC1 knockdown in Hep3B2.1 cells. RNA sequencing iden… Show more
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