2011
DOI: 10.1152/ajplung.00270.2010
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CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia

Abstract: S. CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol 300: L330 -L340, 2011. First published January 14, 2011; doi:10.1152/ajplung.00270.2010.-The pathological hallmarks of bronchopulmonary dysplasia (BPD), one of the most common long-term pulmonary complications associated with preterm birth, include arrested alveolarization, abnormal vascular growth, and variable interstiti… Show more

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Cited by 67 publications
(85 citation statements)
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“…Alveolarization was assessed on hematoxylin-eosin stained tissue sections by radial alveolar count and by mean linear intercept as previously described (41,42).…”
Section: Animal Model and Experimental Protocolmentioning
confidence: 99%
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“…Alveolarization was assessed on hematoxylin-eosin stained tissue sections by radial alveolar count and by mean linear intercept as previously described (41,42).…”
Section: Animal Model and Experimental Protocolmentioning
confidence: 99%
“…Ten random images were taken with the ×20 objective on each von Willebrand factor-stained slide. The vascular density was expressed as the average number of von Willebrand factor-positive vessels (15-50 µm) counted per high-power field as previously described (42).…”
Section: Animal Model and Experimental Protocolmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent studies from our laboratory utilizing genetic gain-of-function and biological loss-of-function approaches have provided compelling evidence that a novel signaling network orchestrated by CTGF plays an important role in BPD pathogenesis (6,11,12). In our novel transgenic mouse model, targeted overexpression of CTGF in alveolar type II epithelial (AT II) cells induces the pathological hallmarks of severe BPD, including decreased alveolar and vascular development and increased vascular remodeling and PH (12). In contrast, in a hyperoxia-induced rat model of BPD, administration of a CTGF-neutralizing antibody improved alveolar and vascular development and decreased pulmonary vascular remodeling and PH (6).…”
Section: Introductionmentioning
confidence: 99%
“…Multiple studies have examined the potential role of CTGF in experimental BPD and demonstrated that increased CTGF expression is associated with chronic hyperoxia as well as mechanical ventilationinduced lung injury in neonatal rodents (6-10). Recent studies from our laboratory utilizing genetic gain-of-function and biological loss-of-function approaches have provided compelling evidence that a novel signaling network orchestrated by CTGF plays an important role in BPD pathogenesis (6,11,12). In our novel transgenic mouse model, targeted overexpression of CTGF in alveolar type II epithelial (AT II) cells induces the pathological hallmarks of severe BPD, including decreased alveolar and vascular development and increased vascular remodeling and PH (12).…”
mentioning
confidence: 99%