CTCF-activated SNHG16 facilitates gastrointestinal stromal tumor by targeting miR-128-3p/CASC3 axis

Yang, Zhen; Pu, Minglong; Dong, Xinhua; Yang, Hongwei; Chang, Weilong; Liu, Tao; Zhang, Xiefu

doi:10.1016/j.yexcr.2022.113131

Cited by 2 publications

(2 citation statements)

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“…For example, silencing the expression of SNHG16 could attenuate the proliferation, activate the apoptosis, and inhibit the migratory, invasive and malignant phenotype in GC cell lines. In addition, the knockdown of SNHG16 could reduce tumor volume and weight in a nude mouse human-GC xenograft model ( 173 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it has been shown that SNHG16 can promote EMT by downregulating the WNT signaling pathway and inhibiting DKK3 expression, and can regulate β-catenin protein expression without participating in the β-catenin translocation between the cytoplasm and nucleus ( 172 ). In particular, SNHG16 activated by CCCTC binding factor (CTCF) can modulate gastrointestinal stromal tumor cell proliferation, migration, invasion and apoptosis through the miR-128-3p/CASC3 axis ( 173 ). In another study, SNHG16 was also demonstrated to be able to mediate the upregulation of JAK2 and STAT3 by sponging miR-135a to influence the proliferation, invasion and apoptosis of GC cells, with SNHG16 being regulated by phosphorylated-STAT3 directly or indirectly ( 174 ).…”

Section: Snhg16 and Human Digestive System Cancermentioning

confidence: 99%

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Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review)

Zhao,

Kan,

Wang

et al. 2024

Oncol Rep

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The incidence of tumors in the human digestive system is relatively high, including esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer. These malignancies arise from a complex interplay of environmental and genetic factors. Among them, long non-coding RNAs (lncRNAs), which cannot be translated into proteins, serve an important role in the development, progression, migration and prognosis of tumors. Small nucleolar RNA host gene 16 (SNHG16) is a typical lncRNA, and its relationship with digestive system tumors has been widely explored. The prevailing hypothesis suggests that the principal molecular mechanism of SNHG16 in digestive system tumors involves it functioning as a competitive endogenous RNA that interacts with other proteins, regulates various genes and influences a downstream target molecule. The present review summarizes recent research on the relationship between SNHG16 and numerous types of digestive system cancer, encompassing its biological functions, underlying mechanisms and potential clinical implications. Furthermore, it outlines the association between SNHG16 expression and pertinent risk factors, such as smoking, infection and diet. The present review indicated the promise of SNHG16 as a potential biomarker and therapeutic target in human digestive system cancer.

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Section: Discussionmentioning

confidence: 99%