CTC, ctDNA, and Exosome in Thyroid Cancers: A Review

Wang, Wenwen; Zheng, Zhiyao; Lei, Jianyong

doi:10.3390/ijms241813767

Cited by 4 publications

(2 citation statements)

References 157 publications

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“…The heterogeneity of exosomes poses both methodological hurdles and promising potential for diagnostics and therapeutic procedures 120–123 . Numerous studies have provided compelling evidence indicating that malignant brain cancer cells exhibit a notable increase in the release of exosomes into the extracellular environment, which can be attributed, at least in part, to metabolic reprogramming and lactate production.…”

Section: Exosomes Mediate “Wireless Communications” Between the Nervo...mentioning

confidence: 99%

Progress in cancer neuroscience

Lan,

Zou,

Wang

et al. 2023

MedComm

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Cancer of the central nervous system (CNS) can crosstalk systemically and locally in the tumor microenvironment and has become a topic of attention for tumor initiation and advancement. Recently studied neuronal and cancer interaction fundamentally altered the knowledge about glioma and metastases, indicating how cancers invade complex neuronal networks. This review systematically discussed the interactions between neurons and cancers and elucidates new therapeutic avenues. We have overviewed the current understanding of direct or indirect communications of neuronal cells with cancer and the mechanisms associated with cancer invasion. Besides, tumor‐associated neuronal dysfunction and the influence of cancer therapies on the CNS are highlighted. Furthermore, interactions between peripheral nervous system and various cancers have also been discussed separately. Intriguingly and importantly, it cannot be ignored that exosomes could mediate the “wireless communications” between nervous system and cancer. Finally, promising future strategies targeting neuronal–brain tumor interactions were reviewed. A great deal of work remains to be done to elucidate the neuroscience of cancer, and future more research should be directed toward clarifying the precise mechanisms of cancer neuroscience, which hold enormous promise to improve outcomes for a wide range of malignancies.

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Section: Exosomes Mediate “Wireless Communications” Between the Nervo...mentioning

confidence: 99%

Progress in cancer neuroscience

Lan,

Zou,

Wang

et al. 2023

MedComm

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“…Among these biomarkers, CTCs, cell-free DNA (cfDNA), and RNA provide a dynamic glimpse into the tumor's genetic landscape. This revolutionary approach offers promising avenues for early cancer detection, monitoring disease progression, and tailoring personalized treatment strategies [3].…”

Section: Introductionmentioning

confidence: 99%

The Role of Circulating Tumor Cells as a Liquid Biopsy for Cancer: Advances, Biology, Technical Challenges, and Clinical Relevance

Allen

2024

Cancers

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Cancer remains a leading cause of mortality worldwide, with metastasis significantly contributing to its lethality. The metastatic spread of tumor cells, primarily through the bloodstream, underscores the importance of circulating tumor cells (CTCs) in oncological research. As a critical component of liquid biopsies, CTCs offer a non-invasive and dynamic window into tumor biology, providing invaluable insights into cancer dissemination, disease progression, and response to treatment. This review article delves into the recent advancements in CTC research, highlighting their emerging role as a biomarker in various cancer types. We explore the latest technologies and methods for CTC isolation and detection, alongside novel approaches to characterizing their biology through genomics, transcriptomics, proteomics, and epigenetic profiling. Additionally, we examine the clinical implementation of these findings, assessing how CTCs are transforming the landscape of cancer diagnosis, prognosis, and management. By offering a comprehensive overview of current developments and potential future directions, this review underscores the significance of CTCs in enhancing our understanding of cancer and in shaping personalized therapeutic strategies, particularly for patients with metastatic disease.

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