CT60 A/G marker of the 3′-UTR of the CTLA4 gene and liver transplant

Evaluation of CTLA-4, CD28 and CD86 Genes Polymorphisms in Acute Renal Allograft Rejection among Tunisian Patients

“…Our findings can join those of Kim et al who reported the implication of the (+49) G allele of CTLA-4 in late acute rejection kidney allograft (Kim et al, 2010), and also those of Marìn et al who revealed an association of the (+1057) G allele of CD86 and acute rejection in liver allograft (Marìn et al, 2005). In contrast to us, Muro et al study shows that the potential correlated allele of CTLA-4 gene to liver acute rejection is the (+6230) G (Muro et al, 2008). Slavcheva et al rather revealed a lack of association between CTLA-4 (+49) A/G polymorphism and renal or liver acute rejection, and a possible implication of alleles 92 and 94 bp of the (AT)n microsatellite (Slacheva et al, 2001).…”

Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients

“…The association of CTLA4 and acute rejection of liver allograft has been shown in three separate studies (de Reuver et al, 2003;Haimila et al, 2004;Minguela et al, 2000;Slavcheva et al, 2001), but another study by Muro M and his coworkers could not demonstrate this association (Muro et al, 2008). Accordingly, it is proposed that genetic variation of co-stimulatory genes may regulate the level of immune activation and modulate the graft rejection susceptibility.…”

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“…19 The results did not show any significant differences between the genotypes or allele distribution and AR or noAR patients. The CTLA-4 CT60 G allele and liver AR were related in the study by Muro and coworkers, 13 but in another study, Azarpira and associates did not observe any association between CTLA-4 CT60 and liver AR. 46 Marder and associates studied the association of CTLA-4-318, +49AG, and CD28 gene polymorphisms with liver transplant outcomes.…”

“…6,10,12 However, Muro and coworkers did not observe this association. 13 The CTLA-4 exon 1, where the +49 polymorphism is located, encodes the leader peptide of the protein responsible for CTLA-4 trafficking to the endoplasmic reticulum. Traditionally, the A allele has been identified as the 02, log-rank test) among total transplant patients, where the T.C, T.T, and C.C genotypes were combined.…”

“…The association of CTLA-4 and acute rejection (AR) of liver allografts has been shown in 3 separate studies, 6,[10][11][12] but another study by Muro and coworkers did not demonstrate this association. 13 Therefore, it was proposed that genetic variation of costimulatory genes may regulate the level of immune activation and modulate graft rejection susceptibility. The most commonly studied CTLA-4 single nucleotide polymorphisms (SNPs) are promoter -318 C.T and exon 1+49 A.G, of which the A allele CTLA+49 A.G gene polymorphism was reported as a risk allele in liver transplant patients.…”