CT temporal subtraction method for detection of sclerotic bone metastasis in the thoracolumbar spine

CT temporal subtraction: techniques and clinical applications

“…Figure 2 shows the notion of the registration scheme. An image warping technique such as voxel matching is applied to the current and the previous image (30), as shown in Figure 2A and Figure 2C, respectively, in order to get shift vectors, which represent the extent of deformation (or warping) of the previous image relative to the current image. These shift vectors on the current image will enable us to warp the previous image to produce a TS image.…”

“…Several clinical studies using CT-TS technique indicate the improvement of diagnostic ability for lung nodule and bone metastasis detection (28,30,(36)(37)(38)(39)(40)(41)(42). The performance for the detection of lung nodule and bone metastasis was summarized in Table 1.…”

Pattern Recognition in Musculoskeletal Imaging Using Artificial Intelligence

“…Computer-aided methods for bone metastases detection from serial CT scans have also been developed. [32][33][34] Oh et al presented an automatic method to detect changes in bone metastases through the subtraction of two registered CT volumes on longitudinal examinations using weighted-Demons registration, symmetrical warping subtraction, as well as Jacobian and false-positive suppressions. 32 Changes in sclerotic or lytic bone lesions in the chest, including at the spine, ribs, and sternum, could be identified within 3 minutes with a sensitivity (false-positive rate per patient) of 92.6% (9.71) and with 24% of lesions missed by radiologists but identified by the software and confirmed to represent true metastases.…”

“…6). 34 Few studies have been published regarding marrow lesion detection on CT or the use of whole-body magnetic resonance imaging (MRI) for spine metastases. Martínez-Martínez et al introduced an automated technique to discern bone marrow infiltration in femurs on low-dose CT in patients with multiple myeloma, capable of distinguishing femurs with and without bone marrow infiltration with an area under the curve (AUC) of 0.996.…”

Analgesia from percutaneous thermal ablation plus cementoplasty for cancer bone metastases

“…It is estimated that approximately 26% to 45% of patients with advanced prostate, breast, lung, and thyroid cancer will develop bone metastasis [5], [6], [7], [8]. As the number of patients being diagnosed with cancer rises, the incidence of bone metastases increases as well [9], [10], [11]. Extensive pain, distressing and insomnia caused by pathological bone fractures and spinal cord compression in patients with bone metastases are major factors which further deteriorate the quality of their life [3].…”