CT scan evaluation of glenoid bone and pectoralis major tendon: interest in shoulder prosthesis

Obert, L.; Peyron, Christelle; Boyer, Etienne; Menu, Gauthier; Loisel, François; Aubry, S.

doi:10.1051/sicotj/2016021

Cited by 8 publications

(7 citation statements)

References 37 publications

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“…The orientation of the scapular blade – also termed the “scapular border (SB)” – is the most commonly used such reference [ 9 ]. However, anatomical studies report significant variabilities in glenoid orientation (version, inclination, and rotation) relative to the scapula blade in normal non-arthritic scapulae [ 9 , 10 ], with measures of retroversion ranging from −5° to 10° [ 11 , 12 ]. All these factors influence the SB, and as a result, relying on a reference with such variability to plan or navigate in TSA may be misleading.…”

Section: Introductionmentioning

confidence: 99%

The Glenoid Vault Outer Cortex a new more accurate radiological reference for shoulder arthroplasty

Hurst

Merlini

Hansen

et al. 2021

SICOT-J

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Introduction: Correct positioning of the glenoid component is an important determinant of outcome in shoulder arthroplasty. We describe and assess a new radiological plane of reference for improving the accuracy of glenoid preparation prior to component implantation – the Glenoid Vault Outer Cortex (GvOC) plane. Methods: One hundred and five CT scans of normal scapulae were obtained. Forty six females and 59 males aged between 22 and 30 years. The accuracy of the GvOC plane was then compared against the current “gold standard” – the scapular border (SB). Measurements of glenoid inclination, version, rotation, and offset were obtained using both the GvOC and SB planes. These were then compared to actual values. Results: The mean difference between version obtained using the GvOC plane and the actual value was 1.8° (−2 to 5, SD 1.6) as compared to 6.7° (−2 to 17, SD 4.3) when the SB plane was used, (p < 0.001). The mean difference between estimates of inclination obtained using the GvOC plane and the actual were 1.9° (−4 to 6, SD 1.6) as compared to 11.2° (−4 to 25, SD 6.1) when the SB plane was used, (p < 0.001). Conclusions: The GvOC plane produced estimates of glenoid version and inclination closer to actual values with lower variance than when the SB plane was used. The GvOC may be a more accurate and reproducible radiological method for surgeons to use when defining glenoid anatomy prior to arthroplasty surgery.

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Section: Introductionmentioning

confidence: 99%

The Glenoid Vault Outer Cortex a new more accurate radiological reference for shoulder arthroplasty

Hurst

Merlini

Hansen

et al. 2021

SICOT-J

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“…In the neuroimaging eld, numerous groups have adapted different forms of ICC for assessing test-retest reliability in different applications of functional brain imaging [9,10]. Braun et al used ICC (3,1) and ICC (2,1) to study the reliability of a functional magnetic resonance imaging (fMRI)based graph theoretical approach [11]. In this study, ICC was used to quantify the reliability of MPR for measuring GT.…”

Section: Introductionmentioning

confidence: 99%

“…There was no report about measurement of the precise size about greater tuberosity. There were several study reporting methods of bone structure measurement, including computed tomography (CT), 3D-CT imaging and magnetic resonance imaging (MRI) [2][3][4]. Most of these studies reported methods by CT measurement and multiplanar reconstruction (MPR) [5].…”

Section: Introductionmentioning

confidence: 99%

How Great is Greater Tuberosity? – A Analysis by CT Multiplanar Reconstruction

Yin

et al. 2021

Preprint

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Objective: This study was designed to explore the precise size of the greater tuberosity of humerus in Chinese population.Methods: The radiologic study was performed on 66 CTs of shoulder from the hospital’s CT scan database of out-patient department from December 2018 to February 2020. This study designed a method to measure the size of the greater tuberosity (GT). The width, height and thickness of the greater tuberosity were measured on CT image multiplanar reconstructions (MPR), which was independently conducted by two observers.Results: 66 intact shoulders CT scans were analyzed, including 26 women and 40 men with a mean age of 36.79 ± 9.17 years, with 41 right and 25 left shoulders. There were no significant differences in GT width, GT height, GT thickness and PH thickness between two observers. The ICC for the GT width measurements taken by CT was 0.872. The ICC for the GT height was 0.810. The ICC for the GT thickness was 0.777. The ICC for the PH thickness was 0.971. For male cases, the total PH thickness was 51.06±2.30 (45.70-55.20) mm for female cases, the total PH thickness was 45.79±2.57 (41.40-51.25) mm. Gender have a significant impact on the results, man had a larger GT than woman.Conclusions: The method was an applicable way the measure the size of greater tuberosity, it showed good reliability. The size of GT in male cases was larger than female. These data provides important information for further research and clinical practice.

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“…1–3 Peri-prosthetic osteolysis can be detected by radiographic techniques, such as CT, planar X-ray or MRI, as the pathology develops. 4, 5 Unfortunately, when the peri-implant osteolysis is radiographically confirmed, the condition is mostly irreversible, leaving revision surgery as the only treatment option which is more expensive, and often associated with poorer clinical outcomes. 6–8 Currently there is no US FDA approved therapeutic intervention for aseptic implant loosening.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

Wei

Zhao

et al. 2017

Mol. Pharmaceutics

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N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymers were previously found to represent a versatile delivery platform for the early detection and intervention of orthopedic implant loosening. In this manuscript, we evaluated the impact of different structural parameters of the HPMA copolymeric system (e.g. molecular weight (MW), drug content) to its pharmacokinetics and biodistribution (PK/BD) profile. Using 125I, Alexa Fluor® 488 and IRDye® 800 CW-labeled HPMA copolymer-dexamethasone (P-Dex) conjugates with different MW and dexamethasone (Dex) contents, we found the MW to be the predominant impact factor on the PK/BD profiles of P-Dex, with Dex content as a secondary impact factor. In gamma counter-based PK/BD studies, increased MW of P-Dex reduced elimination, leading to lower clearance, longer half-life, and higher systemic exposure (AUC and MRT). In the semi-quantitative live animal optical imaging evaluation, the distribution of P-Dex to the peri-implant inflammatory lesion increased when MW was increased. This result was further confirmed by FACS analyses of cells isolated from peri-implant regions after systemic administration of Alexa Fluor® 488-labeled P-Dex. Since the in vitro cell culture study suggested that the internalization of P-Dex by macrophages is generally independent of P-Dex’ MW and Dex content, the impact of the MW and Dex content on its PK/BD profile was most likely exerted at physiological and pathophysiological levels rather than at the cellular level. In both gamma counter-based PK/BD analyses and semi-quantitative optical imaging analyses, P-Dex with 6 wt% Dex content showed fast clearance. Dynamic light scattering analyses unexpectedly revealed significant molecular aggregation of P-Dex at this Dex content level. The underlining mechanisms of the aggregation and fast in vivo clearance of the P-Dex warrant further investigation.

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CT scan evaluation of glenoid bone and pectoralis major tendon: interest in shoulder prosthesis

Cited by 8 publications

References 37 publications

The Glenoid Vault Outer Cortex a new more accurate radiological reference for shoulder arthroplasty

The Glenoid Vault Outer Cortex a new more accurate radiological reference for shoulder arthroplasty

How Great is Greater Tuberosity? – A Analysis by CT Multiplanar Reconstruction

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

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