CT Perfusion of Head and Neck Tumors: How We Do It

Faggioni, Lorenzo; Neri, Emanuele; Bartolozzi, Carlo

doi:10.2214/ajr.09.3187

Cited by 44 publications

(24 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with the results of Faggioni and co-workers who were the first to show that CTP values differ not only between tumours and muscle tissue, but also between tumour lesions and the contralateral healthy side [20]. These characteristics and perfusion values are based on the The reason for the significant different perfusion parameters compared to tumours is the increased perfusion demand based on an enlarged neovascular bed evoked by tumoral neoangiogenesis with consecutive intratumoral arteriovenous shunts [20,23]. This physiological concept has been also demonstrated by the correlation between BF (and additionally but not significantly so, BV) and tumour microvessel density [23,24].…”

Section: Tumour Vs Healthy Contralateral Tissuesupporting

confidence: 92%

“…tumour lesion glycolysis (TLG) and PETvol (tumour volume measured with PET) [16][17][18][19]. Also, there is only very limited information about the relationship among CTP values in ENT tumours and metastatic lymph nodes, healthy contralateral tissue and no information in comparison to inflammatory lesions [20,21]. It is very clear in theory that CTP and PET are measuring different parts of tumour characteristics e.g.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Combined PET/CT-perfusion in patients with head and neck cancers

et al. 2012

View full text Add to dashboard Cite

Objectives Computed tomography perfusion (CTP) can provide information about angiogenesis and blood-flow characteristics in tumours.[18F]Fluoro-2-deoxy-D-glucosepositron emission tomography/computed tomography (FDG-PET/CT) is one of the major oncological imaging techniques which provides information about viability of the tumour cell and partly also about its aggressiveness. The aim of the study was to investigate the relationship between FDG and CTP data in patients with head and neck cancers.Materials and methods Forty-one patients with a clinically suspected head and neck cancer were prospectively included. All patients underwent a combined PET/CT with an integrated CTP examination in the area of the head and neck tumour. CTP data (BF, BVand MTT) and PET data (SUVmax, SUVmean, TLG, PETvol) were compared between tumours and (1) healthy contralateral tissue, (2) inflammatory lesions, (3) metastatic lymph nodes, and CTP data and PET data were correlated in tumours. Results Thirty-five patients had a head and neck cancer. All CTP data were statistically different between tumours, inflammatory lesions, healthy tissue and metastatic lymph nodes; PET/CT data were in part significantly different. CTP and PET parameters were not significantly correlated. Conclusion CTP and PET parameters were not significantly correlated; thus, the additional CTP values provide additional insights into tumour behaviour and their glycolytic status. Key Points • Computed tomography perfusion (CTP) can be performed in combined positron emission tomography (PET)/CT.• CTP in addition to PET provides additional insights into tumour behaviour.• CTP can possibly differentiate between head and neck tumours and inflammatory lesions.

show abstract

Section: Tumour Vs Healthy Contralateral Tissuesupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Combined PET/CT-perfusion in patients with head and neck cancers

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Increasing concern regarding radiation dose to the normal tissues in patients undergoing CTP has led to using lower kilovoltage settings. Although 80 kV has been used for brain perfusion as well as more recent neck perfusion studies, 23 120 kV with 60 mA has been used for most published CTP studies for head and neck cancers; 5,8,9,24 therefore, we used 120 kV in this study with 50 mA, decreased from 60 mA. Future studies could be performed with lower kilovoltage and milliampere settings to minimize radiation if appropriate perfusion data could be maintained.…”

Section: Discussionmentioning

confidence: 99%