CT or MRI Which is better for Rectal Cancer Imaging?

Rajul, Rastogi; Meena, G. L.; Gupta, Yuktika; Sinha, Pragya; Das, Pankaj; Chaudhary, Mohini; Pratap, Vijai

doi:10.21767/2471-9943.100028

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Different cross-sectional imaging tools as CT (computed tomography), PET/CT (positron emission tomography/computed tomography), and MRI (magnetic resonance imaging) are usually used for initial assessment, staging, and follow-up of therapeutic response of cancers [8][9][10][11]. Contrast enhanced magnetic resonance imaging is considered a routine tool used in colorectal cancer local staging, yet it is invasive, time consuming, and adequate cooperation in breath hold technique which is required in addition to contrast media contraindications and adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Role of diffusion-weighted MRI in diagnosis and post therapeutic follow-up of colorectal cancer

Sabry

Rady

Niazi

et al. 2021

Egypt J Radiol Nucl Med

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Background The colorectal cancer (CRC) is one of the deadliest cancers in the world. Local tumor stage, vascular or lymphatic invasion, and tumor grade are essential for accurate management. The main imaging modality for initial assessment and therapeutic response evaluation of CRC is magnetic resonance imaging (MRI). The purpose of this prospective study was to illustrate the role of diffusion-weighted MRI (DWI) and apparent diffusion coefficient (ADC) value in initial assessment and grading of colorectal carcinoma as well as evaluation of its response to chemotherapy or combined chemoradiation. Results Restricted diffusion in DWI was found in 37 out of 40 patients with sensitivity of about 92.5%. In the studied group, the median ADC value was 1.21 (min 0.80, max 1.31) and the average ADC value was 1.14 ± 0.161. The mean ADC value in poorly differentiated tumors was 0.979 × 10−3mm2/s. The mean ADC value in moderately differentiated tumors was 1.112 × 10−3mm2/s. The mean ADC value in well-differentiated tumors was 1.273 × 10−3mm2/s. The sensitivity, specificity, PPV, NPV, and accuracy were higher with addition of DWI and ADC value to conventional MRI reaching 100%, 80%, 83.3%, 100%, and 90%, respectively. Conclusion Adding DW imaging with ADC value to conventional MRI yields better diagnostic accuracy than using conventional MR imaging alone in detection, correlation with tumor histologic grade, initial staging, and response evaluation to neoadjuvant chemoradiotherapy in patients with locally advanced colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Role of diffusion-weighted MRI in diagnosis and post therapeutic follow-up of colorectal cancer

Sabry

Rady

Niazi

et al. 2021

Egypt J Radiol Nucl Med

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“…Tumour staging included abdominal, and chest CT (computed tomography) or MRI and/or endosonography [ 14 ]. After oncological treatment, restaging (CT or MRI) [ 15 , 16 ] was performed. Prior to surgery, preoperative work-up was carried out (laboratory tests, coagulation parameters, blood type test, chest X-ray, cardiac assessment and consultation with an anaesthetist).…”

Section: Methodsmentioning

confidence: 99%

Clinical benefits of oral capecitabine over intravenous 5-fluorouracyl regimen in case of neoadjuvant chemoradiotherapy followed by surgery for locally advanced rectal cancer

Paszt¹,

Ottlakán²,

Ábrahám³

et al. 2022

Pathol. Oncol. Res.

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Background: During the last decade, one of the most important treatment options for locally advanced, potencially resectable rectal tumours was neoadjuvant chemoradiotherapy (CRT) followed by surgery.Methods: Effects of the neoadjuvant treatment on surgical outcomes were retrospectively analysed in 185 patients with stage T2–T4 and N0–2, resectable rectal tumour among two patient groups defined by radiosensitizer agents. Group 1 (n = 94) involved radiotherapy (RT) with 50.4 Gy total dose (25 × 1.8 Gy + 3 × 1.8 Gy tumour bed boost), and intravenous 5-fluorouracil (5-FU) (350 mg/m2) with leucovorin (20 mg/m2) on the 1–5 and 21–25 days, while Group 2 (n = 91) RT and orally administrated capecitabine (daily 2 × 825 mg/m2) on RT days. Surgery was carried out after 8–10 weeks. Side effects, perioperative complications, type of surgery, number of removed regional lymph nodes, resection margins and tumour regression grade (TRG) were analysed.Results: More favourable side effects were observed in Group 2. Despite the same rate of diarrhoea (Group 1 vs. Group 2: 54.3% vs. 56.0%), Grade 2–3 diarrhoea ratio was lower (p = 0.0352) after capecitabine (Group 2). Weight loss occurred in 17.0% and 2.2% (p = 0.00067), while nausea and vomiting was described in 38.3% and 15.4% (p = 0.00045) with 5-FU treatment and capecitabine respectively. Anaemia was observed in 33.0% and 22.0% (p = 0.0941). Complete tumour regression occurred in 25.3% after oral- and 13.8% after intravenous treatment (p = 0.049). Ratio of sphincter preservation was higher with laparoscopy than open surgery (72.3% vs. 39.7%) (p = 0.00001).Conclusion: The study confirms advantages of neoadjuvant chemoradiotherapy with oral capecitabine for rectal tumours, such as more favourable side effect profile and overall clinical outcome, with increased rate of complete tumour regression.

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CT or MRI Which is better for Rectal Cancer Imaging?

Cited by 2 publications

References 9 publications

Role of diffusion-weighted MRI in diagnosis and post therapeutic follow-up of colorectal cancer

Role of diffusion-weighted MRI in diagnosis and post therapeutic follow-up of colorectal cancer

Clinical benefits of oral capecitabine over intravenous 5-fluorouracyl regimen in case of neoadjuvant chemoradiotherapy followed by surgery for locally advanced rectal cancer

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