CT, MR and EPR imaging of graphene oxide aerogels

Tadyszak, Krzysztof; Wereszczyńska, Beata; Gonet, Michał

doi:10.1016/j.solidstatesciences.2020.106402

Cited by 5 publications

(6 citation statements)

References 49 publications

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“…For example, covalently functionalized graphene sheets were prepared by grafting a well-defined thermo-responsive poly( N -isopropylacrylamide) (PNIPAM) via click chemistry, thus loading by π–π stacking interactions a water-insoluble anticancer drug, camptothecin (CPT), with a superior loading capacity of 15.6 wt % [ 217 ]. Kakran et al pursued their studies in the development of multifunctional GO sheets carrying Tween 80, poly(ethylene glycol)- block -poly(propylene glycol)- block -poly(ethylene glycol) moieties and maltodextrin so as to load a high amount of poorly soluble anticancer drugs such as ellagic acid by π–π stacking adsorption [ 218 ]. Using this approach, they demonstrated that a pH-dependent drug release occurred, suggesting also that GO did not hamper the scavenger properties of the payload.…”

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

“…On the other hand, metal/GO nanocomposites provide the proper combination of magnet [ 219 , 220 , 221 ], MRI/CT imaging [ 218 ], drug delivery and photothermal [ 15 , 222 ] properties that make them powerful all-in-one tools useful in advanced cancer theranostic applications. These characteristics are highly desired in cancer theranostics for the development of efficient smart agents for precision cancer therapy applications.…”

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

“…Using this theranostic nanoprobe, in vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging were carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice under the guidance of imaging [ 142 ]. Gold nanoparticles/GO nanocomposites has been explored as theranostic agents useful in positron emission tomography (PET) imaging as well [ 15 , 205 , 218 ]. In a particular work, GO was functionalized with a six-arm amino-PEG carrying an active targeting ligand (TRC105, a monoclonal antibody that binds CD105), leading to significantly improved tumor uptake of functionalized GO (specific for the neovasculature with little extravasation) and warranting future development of these GO conjugates for cancer-targeted PET/CT-guided drug delivery and PTT [ 250 ].…”

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

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Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

et al. 2021

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Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanoplatform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance—MRI, photoacoustic—PA or computed tomography—CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SPIONs) and carbon nanodots (CDs). Currently, surface functionalization of these nanoplatforms is an extremely useful protocol for effectively tuning their structures, interface features and physicochemical properties. This approach is much more reliable and amenable to fine adjustment, reaching both physicochemical and regulatory requirements as a function of the specific field of application. Here, we summarize and compare the most promising metal- and carbon-based theranostic tools reported as potential candidates in precision cancer theranostics. We focused our review on the latest developments in surface functionalization strategies for these nanosystems, or hybrid nanocomposites consisting of their combination, and discuss their main characteristics and potential applications in precision cancer medicine.

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Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

Section: Synthesis and Properties Of Nano-sized Particles With Theranostic Propertiesmentioning

confidence: 99%

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Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

et al. 2021

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“…28 Tadyszak et al employed X-ray CT in conjunction with magnetic resonance imaging to analyze the pore structure of graphene oxide aerogels at a 3D scale. 29 Li and co-workers used X-ray CT to investigate the macropores, pore volume ratio, and PSD in different ranges for MnO 2 aerogels prepared via freezedrying. 30 Herein, in this contribution, two types of Y 2 O 3 aerogels were synthesized using elaborative sol-gel chemistry, differing only in their microstructure: one constructed with nanoparticles and the other with nanosheets.…”

Section: Introductionmentioning

confidence: 99%

“…Tannert et al utilized X-ray CT combined with N 2 adsorption to determine the pore volume and size of resorcinol-formaldehyde aerogel, revealing the presence of macropores above approximately 75 nm with spherical profiles and low connectivity . Tadyszak et al employed X-ray CT in conjunction with magnetic resonance imaging to analyze the pore structure of graphene oxide aerogels at a 3D scale . Li and co-workers used X-ray CT to investigate the macropores, pore volume ratio, and PSD in different ranges for MnO 2 aerogels prepared via freeze-drying …”

Section: Introductionmentioning

confidence: 99%

Revealing Disparities in Porous Networks Between Yttria Aerogel Assemblies with Nanosheets and Nanoparticles and Their Ultrathermal Insulation and Optical Properties

Wang,

Ma,

Deng

et al. 2023

ACS Appl. Mater. Interfaces

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Recent advancements have introduced anisotropic structures, particularly 2D nanosheets, into aerogels, resulting in unique morphologies and exceptional properties that differ from those assembled by isotropic nanoparticles. However, exploration of the distinct porous networks and the resulting properties is limited. We focus on rare earth yttria (Y 2 O 3 ) aerogels as a case in point and demonstrate the synthesis of aerogels with nanosheet and nanoparticle assemblies using elaborative sol-gel chemistry. With the aid of X-ray computed tomography, three-dimensional visualizations of the aerogels provide relative compressive views of the porous network, revealing that the Y 2 O 3 aerogel assembled by nanosheets possesses a hierarchical pore structure characterized by uneven pore distribution, particularly the presence of macropores throughout; in contrast, these consist of nanoparticles exhibiting a relative uniform pore distribution. High-temperature examinations indicate that the nanosheet aerogels are much more stable with a specific surface area of 64 m 2 •g −1 after being exposed at 1300 °C; meanwhile, the aerogels present durable and efficient thermal insulation performances. The exceptional thermal properties are attributed to the synergistic effects of the nanosheets' crystalline nature and the hierarchical porous network. The nanosheet Y 2 O 3 aerogel also exhibited superior luminescent emission characteristics, further enhancing its potential for various applications. Our findings provide further insights into optimization of the microstructures in nanoporous aerogels, particularly through the utilization of anisotropic nanosheets.

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Variable range hopping conductivity of hydrothermally reduced graphene oxide fibers

Ostrowski,

Synoradzki,

Tomaszewski

et al. 2024

J Mater Sci: Mater Electron

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We report applying the autoclaved hydrothermal method for obtaining conductive reduced graphene oxide (rGO) fibers for potential flexible electronic applications, such as supercapacitors, transistors, or sensing applications. The reduction of GO was performed in the temperature range 120 to 180 °C under increased pressure of ca. 8 bar in a sealed Teflon lined up, stainless steel autoclave. The fiber’s diameter and length were defined by the glass tube used as the mold for reducing GO water suspension (diameter of 600 µm and length of 8 cm). After drying, in an ambient atmosphere, the hydrogel fiber shrinks to ca. 50 µm in diameter and 6 cm in length (collapsed pore structure). The drying process, in addition to enhancing electrical conductivity, also increases the mechanical strength of the fibers due to the stronger overlapping of the graphene flakes. The best performance was observed in the fiber reduced at the highest temperature studied, 180 °C, and a minimum temperature of 120 °C is necessary to obtain a fiber. Electrical conductivity was measured using the 4-probe method. The results were analyzed within the framework of variable range hopping and Arrhenius models to pinpoint the best model describing electrical conductivity in dry rGO fibers.

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CT, MR and EPR imaging of graphene oxide aerogels

Cited by 5 publications

References 49 publications

Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics

Revealing Disparities in Porous Networks Between Yttria Aerogel Assemblies with Nanosheets and Nanoparticles and Their Ultrathermal Insulation and Optical Properties

Variable range hopping conductivity of hydrothermally reduced graphene oxide fibers

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