CT measurement of main pulmonary artery diameter.

Edwards, Pamela J.; Bull, R K; Coulden, Richard

doi:10.1259/bjr.71.850.10211060

Cited by 190 publications

(162 citation statements)

References 4 publications

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“…PT and PB sizes were shown to differ significantly between cases and controls, with these measurements consistent with findings of previous studies. 16,21,34 This, along with the semiautomatic method of segmentation and computation itself, demonstrates the reproducibility of our results.…”

Section: Limitationssupporting

confidence: 66%

Computed Tomography Correlates with Cardiopulmonary Hemodynamics in Pulmonary Hypertension in Adults with Sickle Cell Disease

et al. 2014

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Our objective was to determine whether computed tomography angiography (CTA) measurements of pulmonary artery size can noninvasively assess hemodynamics and diagnose pulmonary hypertension (PH) secondary to sickle cell disease (SCD). Twenty SCD patients with confirmed PH were compared with 20 matched controls. Diameters of the pulmonary artery trunk and branches were measured with CTA and a semiautomatic segmentation algorithm. Measurements were normalized by body size and correlated (Spearman rank) with hemodynamic markers from right-heart catheterization. Receiver operating characteristic (ROC) curves were used to investigate the role of pulmonary artery sizes in diagnosing PH. Analysis of pulmonary artery sizes adjusted for body surface area (BSA) resulted in the most significant discrimination between subjects with PH secondary to SCD and controls (P < 0.001); PH was diagnosed accurately with an area under the ROC curve of 0.99. There was significant correlation between pulmonary artery sizes and body mass index (BMI) and BSA only in controls (r ¼ 0.46-0.68, P < 0.04 for all). The most significant correlations with hemodynamic markers were found between BMIadjusted pulmonary artery sizes and high systolic pulmonary arterial pressure, high pulmonary vascular resistance, high systemic vascular resistance, and low cardiac output (r ¼ 0.47, 0.62, 0.61, and 0.66, respectively; P < 0.04 for all). BMI-adjusted CTA measures of the pulmonary artery relate to high pulmonary vascular resistance and reduced cardiac output in patients with SCD and PH. CTA with quantitative image analysis is a powerful noninvasive diagnostic tool for PH in SCD and shows promise as estimator of hemodynamic markers.

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Section: Limitationssupporting

confidence: 66%

Computed Tomography Correlates with Cardiopulmonary Hemodynamics in Pulmonary Hypertension in Adults with Sickle Cell Disease

et al. 2014

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“…In the literature, most of the papers that have addressed upper normal values for the pulmonary artery have considered only the trunk of the pulmonary artery, and among those performed using axial imaging, 4,[17][18][19][20][21] only four included an adequate number of subjects ( Table 4). The upper normal limit for the trunk diameter of the pulmonary artery, defined as mean diameter + 2 SD, was clearly larger in two of the studies 18,19 than in the other two, 17,21 32.4 and 33.2 mm vs. 29.6 and 30.1 mm, respectively. This may be explained by the difference in slice thickness, 10 mm vs. 5 mm and 2.5 mm.…”

Section: Discussionmentioning

confidence: 99%

The pulmonary artery in patients with Marfan syndrome: a cross-sectional study

Lundby

Rand‐Hendriksen

Hald

et al. 2012

Genetics in Medicine

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Purpose:The objectives of this study were to establish the prevalence of pulmonary artery dilatation in Marfan syndrome using modern radiological methods and to correlate the diameter of the vessel with aortic disease. methods: Magnetic resonance or computed tomography imaging of the pulmonary artery and aorta was performed in 87 patients with proven Marfan syndrome. Diameters of the root and trunk of the pulmonary artery and of the aortic root were measured perpendicular to the long axes of the vessels. Pulmonary artery diameters were measured on axial images, and aortic diameters were assessed on oblique sagittal images. Results:As compared with normal values in the literature, 47 of the 87 patients (54%) had widening of the trunk of the pulmonary artery (≥30 mm). Of these 47, 15% had no sign of disease of the ascending aorta. The mean (SD) ratio between the diameters of the root and trunk of the pulmonary artery was 1.18 (0.155). Multivariate analysis showed that surgery of the ascending aorta and high body surface area were associated with dilatation of the trunk of the pulmonary artery.conclusions: Pulmonary artery dilatation is present in a high proportion of patients with Marfan syndrome as assessed using cutoff values based on measurements in the normal population. Severe disease of the ascending aorta correlates significantly with pulmonary artery trunk dilatation in patients with Marfan syndrome. 2012:14(11):922-927 Genet Med

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“…Main PA diameter of 3.32 cm had 58% sensitivity and 95% specificity for presence of PAH. 47 The mean PAP used in this study was lower than the accepted definition of PH. Multidetector row CT with three-dimensional volume rendering can elucidate pulmonary vein anatomy in the thorax.…”

Section: Chest Computed Tomographymentioning

confidence: 59%