CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia

Abstract

On the basis of epidemiologic characteristics, clinical manifestations, chest images, and laboratory findings, the diagnosis of 2019-nCoV pneumonia was made. After receiving 3 days of treatment, combined with interferon inhalation, the patient was clinically worse with progressive pulmonary opacities found at repeat chest CT (Figure, B). Disclosures of Conflicts of Interest: J. Lei disclosed no relevant relationships. J. Li disclosed no relevant relationships. X.L. disclosed no relevant relationships. X.Q. disclosed no relevant relationships.

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

“…One of the COVID-19 case reports showed a patient at 5 days of fever presented with a cough, coarse breathing sounds of both lungs, and a body temperature of 39.0°C. The patient's sputum showed positive real-time polymerase chain reaction results that confirmed COVID-19 infection [14]. The laboratory studies showed leucopenia with leukocyte counts of 2.91 × 10^9 cells/L of which 70.0% were neutrophils.…”

“…Additionally, a value of 16.16 mg/L of blood C-reactive protein was noted which is above the normal range (0-10 mg/L). High erythrocyte sedimentation rate and D-dimer were also observed [14]. The main pathogenesis of COVID-19 infection as a respiratory system targeting virus was severe pneumonia, RNAaemia, combined with the incidence of ground-glass opacities, and acute cardiac injury [6].…”

“…Clinical features revealed by a chest CT scan presented as pneumonia, however, there were abnormal features such as RNAaemia, acute respiratory distress syndrome, acute cardiac injury, and incidence of grand-glass opacities that led to death [6]. In some cases, the multiple peripheral ground-glass opacities were observed in subpleural regions of both lungs [14] that likely induced both systemic and localized immune response that led to increased inflammation. Regrettably, treatment of some cases with interferon inhalation showed no clinical effect and instead appeared to worsen the condition by progressing pulmonary opacities [14] (Fig.…”

“…In some cases, the multiple peripheral ground-glass opacities were observed in subpleural regions of both lungs [14] that likely induced both systemic and localized immune response that led to increased inflammation. Regrettably, treatment of some cases with interferon inhalation showed no clinical effect and instead appeared to worsen the condition by progressing pulmonary opacities [14] (Fig. 2).…”

Coronavirus Disease (COVID-19): Spectrum of CT Findings and Temporal Progression of the Disease

“…In the progressive phase, most of the COVID-19 lesions progressed rapidly, and corresponded to the severe type clinical classification. Compared to the early stage, the number of lesions increased significantly, with the extent and density of the lesions increasing concurrently (16,17) (Fig. 6).…”