CT imaging of one extended family cluster of corona virus disease 2019 (COVID-19) including adolescent patients and “silent infection”

Xu, Rui; Du, Mingshan; Li, Linfeng; Zhen, Zhiming; Wang, Huiyou; Hu, Xiaofei

doi:10.21037/qims.2020.02.13

Cited by 40 publications

(39 citation statements)

References 14 publications

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“…It was initially reported to be specific for cryptogenic organizing pneumonia [37,38] but was subsequently described in other patients [39]. Recently, this sign was reported in several COVID-19 cases, which may be attributed to disease progression making consolidation developed around GGO or lesion absorption leaving a decreased intensity in the center [5,12,17,40].…”

Section: Reversed Halo Sign or Atoll Signmentioning

confidence: 99%

Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review

et al. 2020

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Coronavirus disease 2019 (COVID-19) outbreak, first reported in Wuhan, China, has rapidly swept around the world just within a month, causing global public health emergency. In diagnosis, chest computed tomography (CT) manifestations can supplement parts of limitations of real-time reverse transcription polymerase chain reaction (RT-PCR) assay. Based on a comprehensive literature review and the experience in the frontline, we aim to review the typical and relatively atypical CT manifestations with representative COVID-19 cases at our hospital, and hope to strengthen the recognition of these features with radiologists and help them make a quick and accurate diagnosis.

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Section: Reversed Halo Sign or Atoll Signmentioning

confidence: 99%

Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review

et al. 2020

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“…Specularly, the "reversed halo sign" or "atoll sign" is the presence of a ring-like area of consolidation with a superimposed rounded GGO [37]. These signs have been reported in association to COVID-19 and is thought to be related to a healing lesion with a lower density core or an evolving lesion around a pre-existing GGO [50,51]. It has previously been described in association with cryptogenic organizing pneumonia and other pulmonary infections [52,53].…”

Section: Halo Sign and Reversed Halo Or Atoll Signmentioning

confidence: 99%

Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists

et al. 2020

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COVID-19 is an emerging infection caused by a novel coronavirus that is moving so rapidly that on 30 January 2020 the World Health Organization declared the outbreak a Public Health Emergency of International Concern and on 11 March 2020 as a pandemic. An early diagnosis of COVID-19 is crucial for disease treatment and control of the disease spread. Real-time reverse-transcription polymerase chain reaction (RT-PCR) demonstrated a low sensibility, therefore chest computed tomography (CT) plays a pivotal role not only in the early detection and diagnosis, especially for false negative RT-PCR tests, but also in monitoring the clinical course and in evaluating the disease severity. This paper reports the CT findings with some hints on the temporal changes over the course of the disease: the CT hallmarks of COVID-19 are bilateral distribution of ground glass opacities with or without consolidation in the posterior and peripheral lung, but the predominant findings in later phases include consolidations, linear opacities, "crazy-paving" pattern, "reversed halo" sign and vascular enlargement. The CT findings of COVID-19 overlap with the CT findings of other diseases, in particular the viral pneumonia including influenza viruses, parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, etc. There are differences as well as similarities in the CT features of COVID-19 compared with those of the severe acute respiratory syndrome. The aim of this article is to review the typical and atypical CT findings in COVID-19 patients in order to help radiologists and clinicians to become more familiar with the disease.

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“…All patients in our analysis tested positive for SARS-CoV-2 by reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2. The samples-from multiple anatomic sites in some children-were collected from the nasopharynx (n=56; (3,14,15,20,22,26,35,37), nose (n=20; (33,34,38)…”

Section: Sars-cov-2 Virus Exposure and Testingmentioning

confidence: 99%

Trends in clinical presentation of children with COVID-19: a systematic review of individual participant data

et al. 2020

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Context: There are sparse patient-level data available for children with novel coronavirus disease (COVID-19). Therefore, there is an urgent need for an updated systematic literature review that analyzes individual children rather than aggregated data in broad age groups. Methods: Six databases (MEDLINE, Scopus, Web of Science, CINAHL, Google Scholar, medRxiv) were searched for studies indexed from January 1 to May 15, 2020 with MeSH terms: children, pediatrics, COVID-19, SARS-CoV-2. 1241 records were identified, of which only unique papers in English with individual patient information and documented COVID-19 testing were included. This review of 22 eligible studies followed Preferred Reporting Items for Systematic Review and Meta-Analyses of individual participant data guidelines. Results: 123 patients from five countries were identified. 46% were females. Median age was five years (IQR=8). At presentation, 62% had fever, 32% had cough, 58% had a single symptom and 21% were asymptomatic. Abnormal chest imaging was seen in 62% (65/105) of imaged and 76.9% (20/26) of asymptomatic children. A minority of children had elevated platelets, CRP, lactate dehydrogenase, and d-dimer. Conclusion: Data from this independent participant data systematic review revealed that the majority of children with COVID-19 presented with either no symptoms or a single, nonrespiratory symptom.

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CT imaging of one extended family cluster of corona virus disease 2019 (COVID-19) including adolescent patients and “silent infection”

Cited by 40 publications

References 14 publications

Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review

Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review

Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists

Trends in clinical presentation of children with COVID-19: a systematic review of individual participant data

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