CT-guided percutaneous biopsies of head and neck masses.

Gatenby, Robert A.; Mulhern, C B; Strawitz, Joseph G.

doi:10.1148/radiology.146.3.6828687

Cited by 25 publications

(14 citation statements)

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“…The earliest observations suggesting that hypoxia could be measured in this disease were based on the use of polarographic needle electrodes 18 . Almost all of the HNSCC patients studied with this technique had measurements made in enlarged draining lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

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Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Evans¹,

Du²,

Chalian³

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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Purpose-EF5, a 2-nitroimidazole hypoxia marker, was used to study the presence, levels and prognostic significance of hypoxia in primary head and neck squamous cell tumors.Methods and Materials-22 patients with newly diagnosed squamous cell carcinoma of the oral cavity, oropharynx or larynx with at least 2 years of clinical follow-up were included in this study. Quantitative analysis of EF5 immunofluorescence was carried out and these data were compared to patient outcome.Results-EF5 immunostaining demonstrated substantial inter-tumoral hypoxic heterogeneity. The majority of cells in all tumors were well oxygenated. Three patterns of EF5 binding in cells were identified using criteria of the cellular region that was stained (peripheral or central) and the relationship of binding to necrosis. We tested the association between EF5 binding levels with eventfree and overall survival, irrespective of the pattern of cellular binding or treatment regime. Patients with tumors containing EF5 binding regions corresponding to severe hypoxia (≤0.1% oxygen) had a shorter event-free survival time than patients with pO 2 values >0.1% (p=0.032). Nodal status was also predictive for outcome.Conclusions-These data illustrate the potential utility of EF5 binding based on quantitative immunohistochemistry of tissue pO 2 and provide support for development of noninvasive hypoxia PET studies with 18 F-EF5.

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Section: Discussionmentioning

confidence: 99%

“…An early study of in vivo hypoxia was performed with polarographic needle electrodes in enlarged, squamous cell carcinoma-containing neck lymph nodes 18 . This work demonstrated that hypoxia could be measured in a minimally invasive manner and that the resulting values were correlated with short-term treatment response 19 .…”

Section: Introductionmentioning

confidence: 99%

Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Evans¹,

Du²,

Chalian³

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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“…[10][11][12][13][14] More recently, experience with image-guided FNA of nonpalpable abdominal and thoracic lesions has been applied in the head and neck region. 15 Using a technique described in previous reports, 4,5 lesions arising in the pericarotid sheath, thyroid gland, skull base, and parapharyngeal, parotid/ submandibular, paratracheal, paraesophageal, paraspinal, and infratemporal regions have been sampled under CT guidance at our institution.…”

Section: Commentmentioning

confidence: 99%

Image-Guided Fine-Needle Aspiration of the Head and Neck

Sack

Weber²,

Weinstein

et al. 1998

Arch Otolaryngol Head Neck Surg

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(1) The cytologic findings were supported clinically and/or histologically in 86 (92%) of the 93 diagnostic computed tomography-guided FNA cases. (2) Unnecessary surgery was avoided in 37% of the patients with recurrent tumor or benign diagnoses by cytologic assessment. (3) Potential pitfalls include false-positive diagnoses after radiation therapy and procedural or sampling limitations for deep neck and paraspinal lesions.

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“…In our study of 67 tumors in the parapharyngeal space, exact classifi cation of the lesion was possible in 92.5% cases with no false positive report or complication. The diagnostic accuracy of various head and neck tumors by cytology including FNAC varies from 80-95% by various authors [9][10][11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Peroral fine needle aspiration cytology of parapharyngeal tumors: a study of 67 cases

Chatterjee¹,

Mondal²

2009

Indian J Otolaryngol Head Neck Surg

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Peroral fi ne needle aspiration cytology (FNAC) was carried out to diagnose parapharyngeal tumors in 67 patients from January 2000 to January 2008. The infl ammatory lesions were excluded in the present study. The age of patients ranged from 6 years to 72 years. Analysis of results showed 35 benign tumors and 32 malignant neoplasms. Correlation with histopathology showed a diagnostic accuracy of 92.5% with no false positive report. No complication was encountered in the present study. FNAC can replace incisional biopsy which may be hazardous in this area. Immediate treatment can be planned based on the FNAC report. Such a large series of parapharyngeal tumors diagnosed by FNAC has hardly been reported in India.

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CT-guided percutaneous biopsies of head and neck masses.

Cited by 25 publications

References 0 publications

Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Patterns and Levels of Hypoxia in Head and Neck Squamous Cell Carcinomas and Their Relationship to Patient Outcome

Image-Guided Fine-Needle Aspiration of the Head and Neck

Peroral fine needle aspiration cytology of parapharyngeal tumors: a study of 67 cases

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