CT-Guided Fine-Needle Aspiration Biopsy of Pulmonary Nodules 8 mm or Less Has a Higher Diagnostic Accuracy than Positron Emission Tomography–CT

Suresh, Shruthi; Salama, Gayle; Ramjit, Amit; Mahfoud, Ziyad; Lee, Kyungmouk Steve; Pua, Bradley B.

doi:10.1016/j.jvir.2017.10.004

Cited by 7 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SERS EpCAM-aptasensors sensitively discriminated the tumor with a volume of 23.471 mm 3 from normal tissue. Such a tumor detection sensitivity of our biosensor is comparable to the average tumor diameter of 8 mm detected by wide-used CT imaging in the clinic . The receiver operating characteristic (ROC) curve exerted a sensitivity/specificity of 0.9411 for tumor-bearing mice over controls (Figure d), suggesting that the SERS EpCAM-aptasensors are excellent classifiers as they specifically detect the exosome levels in plasma.…”

Section: Resultsmentioning

confidence: 59%

“…Such a tumor detection sensitivity of our biosensor is comparable to the average tumor diameter of 8 mm detected by wide-used CT imaging in the clinic. 47 The receiver operating characteristic (ROC) curve exerted a sensitivity/specificity of 0.9411 for tumor-bearing mice over controls (Figure 3d), suggesting that the SERS EpCAMaptasensors are excellent classifiers as they specifically detect the exosome levels in plasma. To surveil the postoperative tumor recurrence, we performed the surgical resection on the mice and then detected plasma exosomes every week after surgical resection.…”

mentioning

confidence: 98%

See 1 more Smart Citation

Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance

et al. 2021

View full text Add to dashboard Cite

Exosome-based liquid biopsy holds great potential in monitoring tumor progression. Current exosome detection biosensors rely on signal amplification strategies to improve sensitivity; however, these strategies pay little attention to manipulating the number of signal reporters, limiting the rational optimization of the biosensors. Here, we have developed a modularized surface-enhanced Raman spectroscopy (SERS) labeling strategy, where each Raman reporter is coupled with lysine as a signal-lysine module, and thus the number of Raman reporters can be precisely controlled by the modularized solid-phase peptide synthesis. Using this strategy, we screened out an optimum Raman biosensor for ultrasensitive exosome detection, with the limit of detection of 2.4 particles per microliter. This biosensor enables a successful detection of the tumor with an average diameter of approximately 3.55 mm, and thus enables successful surveillance of the postoperative tumor recurrence in mice models and distinguishing cancer patients from healthy subjects. Our work provides a de novo strategy to precisely amplify signals toward a myriad of biosensor-related medical applications.

show abstract

Section: Resultsmentioning

confidence: 59%

mentioning

confidence: 98%

Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance

et al. 2021

View full text Add to dashboard Cite

show abstract

“…For small lung nodules, the diagnostic accuracy increases with increasing nodule size. In a small retrospective study of 43 FNA biopsies of sub-8 mm nodules, Suresh et al found a diagnostic accuracy of 81.4% and sensitivity of 88.9%, significantly higher than those of PET-CT alone which had an accuracy of 46.5% and sensitivity of 38.9%, P<0.001 (33). In another retrospective review of 117 core biopsies of nodules measuring 8 mm or less, Zhao et al reported a higher diagnostic accuracy, sensitivity, and specificity of 95.7%, 95.8%, and 95.5% respectively (34).…”

Section: Diagnostic Accuracymentioning

confidence: 95%

“…Provenance and Peer Review: This article was commissioned by the Guest Editors (Scott Swanson, Daniel Dolan) for the series "How to Evaluate, Diagnose and Treat Small Lung Nodules" published in Current Challenges in Thoracic Surgery. The article has undergone external peer review.Peer Review File: Available at https://dx.doi.org/10.21037/ ccts-[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] …”

mentioning

confidence: 99%

The radiologist’s role in pathologic diagnosis of small lung nodules: radiographic methods of tissue acquisition

Cham¹,

Henschke²,

Yankelevitz³

2022

Curr Chall Thorac Surg

View full text Add to dashboard Cite

Over the past decade, chest computed tomography (CT) utilization has steadily increased in conjunction with lung cancer CT screening. As a result, small lung nodules have become an increasingly common finding. CT guided lung biopsy plays a pivotal role in the sampling of these small lung nodules and the subsequent diagnosis of lung cancer. The success of lung biopsies has a substantial downstream impact on diagnosis and treatment planning. It is well-recognized that the efficacy of lung biopsy is both operator-dependent and patient-dependent. Several considerations are necessary for the safe and successful performance of CT-guided lung biopsy. A familiarity with biopsy contraindications and their management can drastically reduce serious complications, such as intractable hemorrhage. Conscientious patient preparation and empathic communication are essential for reducing patient anxiety while increasing patient tolerance for the procedure and its common complications. Strategic and precise nodule-targeting techniques are crucial for obtaining adequate tissue and for improving diagnostic accuracy. On-site cytologic assessment is a powerful tool that can further boost diagnostic yield while also reducing complication rates by eliminating the need for additional biopsy attempts. Vigilant observation and careful assessment throughout the procedure are key factors in the effective mitigation of the most frequently encountered complications.As personalized medicine plays an increasingly integral part in the diagnosis and treatment of early-stage lung cancers, coordination between radiologists, clinicians, pathologists, and the patient becomes especially important.

show abstract

Computed tomography fluoroscopy-guided cutting needle biopsy of pulmonary nodules ≤8 mm: A retrospective study including 117 nodules

Zhao

Matsui

Hiraki

et al. 2020

European Journal of Radiology

View full text Add to dashboard Cite

CT-Guided Fine-Needle Aspiration Biopsy of Pulmonary Nodules 8 mm or Less Has a Higher Diagnostic Accuracy than Positron Emission Tomography–CT

Cited by 7 publications

References 11 publications

Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance

Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance

The radiologist’s role in pathologic diagnosis of small lung nodules: radiographic methods of tissue acquisition

Computed tomography fluoroscopy-guided cutting needle biopsy of pulmonary nodules ≤8 mm: A retrospective study including 117 nodules

Contact Info

Product

Resources

About