CT-guided and computer assisted stereotactic biopsy

Voges, Jürgen; Schröder, R.; Treuer, Harald; Pastyr, O.; Schlegel, Wolfgang; Lorenz, Walter J.; Sturm, Volker

doi:10.1007/bf01401842

Cited by 64 publications

(31 citation statements)

References 21 publications

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“…Three patients were enrolled into the study prospectively according to the following inclusion criteria: (i) pathological lesion on MRI-images suggesting cerebral glioma; (ii) indication for stereotactic biopsy (localization (eg, deeply seated, eloquent brain areas), diffuse growth pattern, multiple lesions). 26 Excluded were cases that had experienced previous radiation therapy and/or chemotherapy. The biopsy material was only taken for study analysis if the radiological diagnosis of a cerebral glioma was confirmed later by histopathology.…”

Section: Spatial Distribution Of ␣Bc In Human Gliomasmentioning

confidence: 99%

αB-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells

Goplen

Bougnaud

Rajčević

et al. 2010

The American Journal of Pathology

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We have previously established two distinct glioma phenotypes by serial xenotransplantation of human glioblastoma (GBM) biopsies in nude rats. These tumors undergo a gradual transition from a highly invasive nonangiogenic to a less-invasive angiogenic phenotype. In a protein screen to identify molecular markers associated with the infiltrative phenotype, we identified ␣-basic-crystallin (␣Bc) , a small heatshock protein with cytoprotective properties. Its increased expression in the infiltrative phenotype was validated by immunohistochemistry and Western blots , confirming its identity to be tumor-derived and not from the host. Stereotactic human GBM biopsies taken from MRI-defined areas verified stronger ␣Bc expression in the infiltrative edge compared to the tumor core. Cell migration assays and immunofluorescence staining showed ␣Bc to be expressed by migrating cells in vitro. To determine ␣Bc function, we altered its expression levels. ␣Bc siRNA depletion caused a loss of migrating tumor cells from biopsy spheroids and delayed monolayer wound closure. In contrast, glioma cell migration in a Boyden chamber assay was unaffected by either ␣Bc knockdown or overexpression, indicating that ␣Bc is not functionally linked to the cell migration machinery. However, after siRNA ␣Bc depletion, a significant sensitization of cells to various apoptotic inducers was observed (actinomycin, tumor necrosis factor ␣, and TNF-related apoptosisinducing ligand [TRAIL]). In conclusion, ␣Bc is overexpressed by highly migratory glioma cells where it plays a functional role in apoptosis resistance. (Am J Pathol

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Section: Spatial Distribution Of ␣Bc In Human Gliomasmentioning

confidence: 99%

αB-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells

Goplen

Bougnaud

Rajčević

et al. 2010

The American Journal of Pathology

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“…7, 28, 53, 58, 72 These rates are slightly higher than rates associated with SBB in people without HIV infection. 16,80,94,133 In post-transplant patients, most focal CNS infections are caused by Aspergillus sp., Candida sp., or other fungal species. One study of 58 cases of brain abscess after bone marrow transplantation noted that only nine (16%) underwent brain biopsy.…”

Section: Brain Biopsymentioning

confidence: 99%

“…7, 28, 53, 58, 72 These rates are slightly higher than rates associated with SBB in people without HIV infection. 16,80,94,133 …”

mentioning

confidence: 99%

Central Nervous System Infection During Immunosuppression

Zunt

2002

Neurologic Clinics

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The central nervous system (CNS) is susceptible to bacterial, viral, and fungal infections. Suppression of the immune system by human immunodeficiency virus (HIV) infection or immunosuppressive therapy after transplantation increases susceptibility to CNS infection and modifies the presentation, diagnosis, and recommended treatment of various CNS infections. This chapter discusses how suppression of the host immune status modifies the presentation, diagnosis, and treatment of selected CNS infections. IMMUNOSUPPRESSION ASSOCIATED WITH HIV INFECTIONNeurologic illness occurs in 40% to 60% of HIV-infected people. 87 Infection of the CNS may occur during any stage of HIV infection, but opportunistic infection occurs only during latestage infection, when the CD 4 count falls below 200 cells/dL. 114 Opportunistic infection may affect the brain or spinal cord, and onset may be acute, subacute, or chronic. The most common opportunistic CNS infections and neoplasms are: Toxoplasma encephalitis (TE), cryptococcal meningitis, primary CNS lymphoma (PCNSL), progressive multifocal leukoencephalopathy (PML), AIDS dementia complex (ADC, also known as HIV-associated dementia), and cytomegalovirus (CMV) encephalitis. 10 Focal brain lesions occur in up to 17% of people with AIDS and are most often caused by TE, PML, or PCNSL. 6 Since the introduction of potent antiretroviral therapy (previously called highly active antiretroviral therapy, or HAART), the incidence of TE and PCNSL has decreased, whereas the incidence of PML has increased. 5, 21, 98, 107 IMMUNOSUPPRESSION ASSOCIATED WITH TRANSPLANTATIONNeurologic complications occur in 30% to 60% of people receiving solid organ transplantation and in 12% to 70% of people receiving bone marrow transplantation (BMT). Complications include infection of the CNS, encephalopathy, seizure, stroke, and peripheral neuropathy. 47, 61, 109 Infection of the CNS occurs in 5% to 10% of transplant patients and most often manifests as brain abscess, encephalitis, or meningitis. 42 Aspergillus fumigatus, Listeria monocytogenes, and Cryptococcus neoformans are the most common causes of CNS infections in post-transplant patients.Immunosuppressive therapy reduces cell-mediated immunity to prevent rejection of transplant and graft versus host disease (GVHD), but this immunosuppression increases risk of infection by fungi, viruses (especially herpesviruses), bacteria, and parasites. In addition, some immunosuppressive agents, notably cyclosporine and tacrolimus Susceptibility to CNS infection after transplantation changes over time. 42, 109 During the initial month, CNS infection is most often caused by common bacterial pathogens or opportunistic pathogens present in either the transplant environment (e.g., Aspergillus species), or host (e.g., Mycobacterium tuberculosis). At 1 to 6 months, immunosuppression is at its highest, resulting in increased susceptibility to CNS infection by the herpesviruses, especially CMV and Epstein-Barr virus (EBV), fungi, and atypical bacteria. Finally, after 6 month...

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ABSTRACT mass should not be taken in consideration, especially in the diagnosis of deeply located, diffused infiltrative or multiple space-occupying lesions, computerized tomography (CT) or MRI-guided stereotactic biopsies have been proven to be safe and reliable by various studies (2,4,(7)(8)(9)(11)(12)(13)15,16,18,19,(21)(22)(23)(25)(26)(27)(28)(29)(31)(32)(33)(34)(35)(36)(37)(38)

Despite the tremendous improvement in neuroradiology and nuclear medicine, especially in magnetic resonance imaging (MRI) and positron emission tomography (PET), definitive diagnosis in most brain lesions require histopathological examination. When a bulk excision of the AIm: Computed tomography (CT)-guided stereotactic brain biopsy has been performed in our clinic since March 1998.

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mentioning

confidence: 99%

Computerized tomography guided stereotactic biopsy of intracranial lesions: report of consecutive 500 cases.

Can

Türkmenoğlu²,

Tanık³

et al. 2016

Turkish Neurosurgery

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mass should not be taken in consideration, especially in the diagnosis of deeply located, diffused infiltrative or multiple space-occupying lesions, computerized tomography (CT) or MRI-guided stereotactic biopsies have been proven to be safe and reliable by various studies (2,4,(7)(8)(9)(11)(12)(13)15,16,18,19,(21)(22)(23)(25)(26)(27)(28)(29)(31)(32)(33)(34)(35)(36)(37)(38) Despite the tremendous improvement in neuroradiology and nuclear medicine, especially in magnetic resonance imaging (MRI) and positron emission tomography (PET), definitive diagnosis in most brain lesions require histopathological examination. When a bulk excision of the AIm: Computed tomography (CT)-guided stereotactic brain biopsy has been performed in our clinic since March 1998. In this prospective study, we examined the patient data undergoing stereotactic biopsy and the results of biopsies in 500 consecutive patients. mATERIAl and mEThODS: Between the dates of March 1998 and January 2015, CT-guided stereotactic biopsies were performed by using the Leksell stereotactic frame system (Elekta Instruments EU, Sweden) in 500 patients. A total of 512 procedures were performed in patients consisting of 184 females (36.8%) and 316 males (63.2%), ages ranging from 3 to 81 years (mean 50.40±16.67). RESUlTS:Conclusive histopathological diagnosis was not achieved in 17(3.3%) of 512 procedures. Of the others, 173 (33.8%) were high-grade gliomas, 103 (20.1%) were low-grade gliomas, 36 (7%) were malignant lymphomas, 34 (6.6%) were other types of brain tumors, 82 (16%) were metastasis and 67 (13.1%) were non-tumoral lesions. Complications were occurred in ten cases: 3 tumoral bleedings, 2 hypertensive cerebral hematomas, 2 peroperative convulsions, 1 epidural hematoma, 1 myocardial infarction and 1 brain edema. The patients who developed myocardial infarction and hypertensive thalamic hematoma died. The mortality was 0.4% and morbidity was 1.6% in 512 procedures.CONClUSION: CT-guided stereotactic biopsy is a reliable and a safe procedure in cases with intracranial lesions when histopathological diagnosis is required for the appropriate treatment.

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CT-guided and computer assisted stereotactic biopsy

Cited by 64 publications

References 21 publications

αB-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells

αB-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells

Central Nervous System Infection During Immunosuppression

Computerized tomography guided stereotactic biopsy of intracranial lesions: report of consecutive 500 cases.

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