CT Features of Primary Cerebral Lymphoma in AIDS and Non-AIDS Patients

Poon, Tung Pui; Matoso, Ivone; Tchertkoff, Victor; Weitzner, Imre; Gade, Marie F.

doi:10.1097/00004728-198901000-00002

Cited by 46 publications

(14 citation statements)

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“…There are distinct differences in radiological features in patients with PCL, depending on the presence or absence of AIDS [38]. In the AIDS population, PCL presents as heterogeneous or ring-like enhancing lesions (irregular nodular type of enhancement), typically isointense to gray matter on T2-weighted MR images, and usually with a moderate perifocal edema (Fig.…”

Section: Primary Cns Lymphomamentioning

confidence: 99%

CNS involvement in AIDS: spectrum of CT and MR findings

Thurnher¹,

Thurnher²,

Schindler³

1997

Eur Radiol

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The brain may be affected by a variety of abnormalities in association with human immunodeficiency virus (HIV) infection. Knowledge of their existence and characteristic imaging features are important to radiologists for detection, diagnosis, and initiation of an appropriate treatment. Although there is a considerable overlap in the imaging characteristics of different entities, some findings are found to be very suggestive of a particular disease. The CT and MR imaging techniques are commonly used in the diagnosis of neurological disorders in acquired immunodeficiency syndrome (AIDS) patients, to verify treatment response and to guide brain biopsy. This review attempts to describe CT and MR features of infectious and malignant brain disorders in HIV-seropositive patients.

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Section: Primary Cns Lymphomamentioning

confidence: 99%

CNS involvement in AIDS: spectrum of CT and MR findings

Thurnher¹,

Thurnher²,

Schindler³

1997

Eur Radiol

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“…Typically, the lesions are large and centrally hypodense with ring or target enhancement and have associated edema with mild mass effect (Sze et al 1987;Poon et al 1989). Lee et al (1986) demonstrated a consistent correlation between the ring enhancement and central hypodensity with the pathologic appearance of central necrosis and preservation of viable tumor cells at the periphery.…”

Section: Radiologymentioning

confidence: 99%

“…Lee et al (1986) demonstrated a consistent correlation between the ring enhancement and central hypodensity with the pathologic appearance of central necrosis and preservation of viable tumor cells at the periphery. In 30-40% of cases, the disease is multicentric, with multiple lesions seen on CT or MR scans (Lee et al 1986;Sze et al 1987;Poon et al 1989). One study suggests that a focal enhancing mass with subependymal spread and hyperattenuation on nonenhanced CT scan were the most reliable features in distinguishing AR-PCNSL and toxoplasmosis (Dina 1991).…”

Section: Radiologymentioning

confidence: 99%

“…Intracranial toxoplasmosis, for example, also appears on CT and MR scans as multiple, bilateral ring or nodular enhancing lesions with mild to moderate edema and mass effect. These lesions are frequently located at the corticomedullary junction and basal ganglia, as are the lesions of AR-PCNSL (Lee et al 1986; Poon et al 1989;Kupfer et al 1990). Although CT and MR scans are regarded as nonspecific, solitary lesions are more likely to represent AR-PCNSL while multiple lesions are more typical of toxoplasmosis.…”

Section: Radiologymentioning

confidence: 99%

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Primary central nervous system lymphoma

Rosenthal¹,

Issa²

2012

Brain Tumors

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“…Das Virus greift die T-Zellen an. Hierdurch werden verschiedene opportunistische Infektionendurch Protozoen, Pilze, Bakterien und Viren -sowie die Bildung maligner Tumoren erm6glicht (Tabelle 1) [1,2,6,12,18,23,24,39,41,43,53,54,57,58]. …”

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Differentialdiagnose der zerebralen Beteiligung bei HIV-Infektionen

Albrecht

Gustorf-Aeckerle

1999

Klin Neuroradiol

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Zusammenfassung: Bei einer HIV-Infektion k6nnen den Verlauf komplizierende Erkrankungen durch das HI-Virus selbst und/oder andere (opportunistische) Erreger sowie Neoplasien auftreten. Am h~iufigsten ist hierbei die direkte Sch~idigung des Zentralnervensystems durch das HI-Virus, die durch Sch~idigung der weiBen und/oder grauen Hirnsubstanz zur Atrophie fª (HIV-assoziierte Enzephalopathie). Die Toxoplasmose ist die h~iufigste sonstige Infektion; meist tritt sie als Reaktivierung einer latenten Infektion auf. Diese und die prim~ir zerebralen Lymphome sind die h~iufigsten intrazerebralen Raumforderungen. Die Differentialdiagnose zwischen beiden Komplikationen kann schwierig sein, da beide zum Teil gleiche Pr~idilektionsorte (Stammganglien, Thalamus) haben und ~ihnliche Erscheinungsformen (nodul~, zentral nekrotisch) zeigen sowie gleichzeitig auftreten k6nnen. Prim~r zerebrale Lymphome (fast immer Non-HodgkinLymphome der B-Zell-Reihe) treten h~iufiger solit~ir auf als die Toxoplasmose; die Herde sind oft auch gr6Ber als 2 cm. Papovaviren verursachen die progressive multifokale Leukenzephalopathie, die neben den bevorzugten asymmetrischen Marklagermanifestationen auch Kortex und U-Fasern mit einbeziehen kann. Im Gegensatz dazu bef~illt das HI-Virus bei der progressiven diffusen Leukenzephalopathie nur die wei6e Substanz in Form einer diffusen, symmetrischen Infiltration. Eine Zytomegalievirus-Infektion ist relativ h~iufig, verl~uft klinisch aber oft stumm; bildgebend sind die Ver~indemngen den HIV-induzierten Ver~inderungen sehr ~ihnlich. Die Magnetresonanztomographie (MRT) ist der Computertomographie (CT) beim Nachweis pathologischer Ver~inderungen ª legen. Anhand des eigenen Befundmaterials werden charakteristische Merkmale der genannten Ver~inderungen sowie die dazugeh6rige Differentialdiagnose dargestellt. Auf weitere Infektionen, zum Beispiel durch Kryptokokken (h~iufigste Pilzinfektion des Zentralnervensystems) oder Bakterien (Tbc), wird hingewiesen. Sehlª HIV-Enzephalopathie -Toxoplasmose -Lymphom -Progressive multifokale Leukenzephalopathie -Zytomegalievirus-Enzephalitis Differential Diagnosis of Cerebral Involvement at Infections with HIVAbstract: During late phases ofan HIV infection complicating diseases can occur, caused by the virus itself and other (opportunistic) infections or neoplasms. The most frequent injury of central nervous system is caused by the HIV itself, shown as HIV encephalitis 1Neuroradiologisches Institut, Katharinenhospital Stuttgart.

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CT Features of Primary Cerebral Lymphoma in AIDS and Non-AIDS Patients

Cited by 46 publications

References 0 publications

CNS involvement in AIDS: spectrum of CT and MR findings

CNS involvement in AIDS: spectrum of CT and MR findings

Primary central nervous system lymphoma

Differentialdiagnose der zerebralen Beteiligung bei HIV-Infektionen

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