CT Features of Peripheral Pulmonary Carcinoid Tumors

Meisinger, Q.; Klein, Jeffrey S.; Butnor, Kelly J.; Gentchos, George; Leavitt, Bruce J.

doi:10.2214/ajr.10.5954

Cited by 68 publications

(70 citation statements)

References 17 publications

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“…Occurrence in the respiratory tract corresponds to 10-30% of all cases, 1-6 with a bronchopulmonary incidence of 0.22 to 1.57/100,000. [2][3][4] They represent up to 2% of lung malignancies, 1,2 often presenting indolent behavior. [1][2][3]5 Histologically, these tumors are classified as typical (76-90%) or atypical.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] They represent up to 2% of lung malignancies, 1,2 often presenting indolent behavior. [1][2][3]5 Histologically, these tumors are classified as typical (76-90%) or atypical. [1][2][3][4] Central bronchial CATUs represent 64-85% of the cases, with a predominance of typical tumors.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3]5 Histologically, these tumors are classified as typical (76-90%) or atypical. [1][2][3][4] Central bronchial CATUs represent 64-85% of the cases, with a predominance of typical tumors. [1][2][3] Typical CATUs affect both sexes, [1][2][3] with some studies reporting a higher prevalence in women.…”

Section: Discussionmentioning

confidence: 99%

“…1 Symptoms are more frequent in tumors at central sites and some of the main manifestations include recurrent pneumonia, chest pain, cough, hemoptysis and localized wheezing. [1][2][3]6,7 These tumors can secrete neuroamines and peptide hormones, especially serotonin, growth hormone and adrenocorticotrophic hormone, and may cause carci- …”

Section: Discussionmentioning

confidence: 99%

“…It is rarely possible to distinguish an endoluminal component, with extension to the parenchyma being the most dominant feature. [1][2][3][7][8][9] On CT scan, the presence of two central sites is common (85% in the main, lobar or segmental bronchi), with an appearance of nodule or ovoid mass, well-defined and regular margins, spontaneously hyperdense, associated or not with a distinct endoluminal component or distal parenchymal complications. Punctual or diffuse calcifications are found in 30% of the cases.…”

Section: 3mentioning

confidence: 99%

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Endobronchial carcinoid tumor: Radiological findings of a clinical case

Queiroz¹,

Santana²,

Filho³

et al. 2018

Rev. Assoc. Med. Bras.

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We describe the case of a female patient, 21 years old, complaining of dyspnea attacks and wheezing 2 years ago. Chest radiography showed volume loss in the left lower lobe and ipsilateral retrocardiac triangular basal opacity. CT scan showed an extensive solid mass with apex protruding into the left main and lower lobar bronchi, causing distal atelectasis. Histopathological and immunohistochemical study of transbronchial biopsy of the lesion revealed a typical carcinoid tumor, confirmed after tumor resection with total left pneumectomy.Keywords: Carcinoid Tumor. Endobronchial. Pulmonary. Typical. Diagnostic Imaging.case report A female 21-year old patient presenting dyspnea and wheezing attacks for two years. She is overweight, has polycystic ovary syndrome and is currently using oral contraceptives. She does not smoke. The patient reported that three radiographs in the past 6 months revealed consolidation in the left lung base. During this period, treatment regimens for pneumonia were used, without clinical or radiological improvement. On auscultation, rhonchi and wheezing were audible at the base of the left hemithorax. Laboratory tests did not point out any abnormalities.A new chest X-ray showed loss of volume in the left lower lobe with triangular basal retrocardiac opacity, apex directed towards the ipsilateral hilum and base next to the diaphragmatic dome ( Figures 1A and 1B).Computed tomography (CT) imaging showed a solid expansive mass with apex protruding into the left source bronchus ("tip of the iceberg" sign 1 ), causing partial obstruction and distal subsegmentar atelectasis, as well as marked enhancement following intravenous contrast administration (Figures 2A, 2B, 2C and 2D).After bronchofibroscopy, which confirmed the endobronchial lesion, the anatomopathological and immunohistochemical investigation of the transbronchial biopsy material showed a well-differentiated (typical) carcinoid tumor ( Figures 3A, 3B and 3C). A CT scan of the abdomen performed for staging failed to show other neoplastic formations. The therapy selected was left total pneumonectomy, which confirmed the histological finding of tumor in a subsequent investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: 3mentioning

confidence: 99%

See 3 more Smart Citations

Endobronchial carcinoid tumor: Radiological findings of a clinical case

Queiroz¹,

Santana²,

Filho³

et al. 2018

Rev. Assoc. Med. Bras.

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CT‐based radiomics for differentiating peripherally located pulmonary sclerosing pneumocytoma from carcinoid

Zhang,

Yang,

et al. 2024

Medical Physics

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BackgroundPulmonary sclerosing pneumocytoma (PSP) and pulmonary carcinoid (PC) are difficult to distinguish based on conventional imaging examinations. In recent years, radiomics has been used to discriminate benign from malignant pulmonary lesions. However, the value of radiomics based on computed tomography (CT) images to differentiate PSP from PC has not been well explored.PurposeWe aimed to investigate the feasibility of radiomics in the differentiation between PSP and PC.MethodsFifty‐three PSP and fifty‐five PC were retrospectively enrolled and then were randomly divided into the training and test sets. Univariate and multivariable logistic analyses were carried to select clinical predictor related to differential diagnosis of PSP and PC. A total of 1316 radiomics features were extracted from the unenhanced CT (UECT) and contrast‐enhanced CT (CECT) images, respectively. The minimum redundancy maximum relevance and the least absolute shrinkage and selection operator were used to select the most significant radiomics features to construct radiomics models. The clinical predictor and radiomics features were integrated to develop combined models. Two senior radiologists independently categorized each patient into PSP or PC group based on traditional CT method. The performances of clinical, radiomics, and combined models in differentiating PSP from PC were investigated by the receiver operating characteristic (ROC) curve. The diagnostic performance was also compared between the combined models and radiologists.ResultsIn regard to differentiating PSP from PC, the area under the curves (AUCs) of the clinical, radiomics, and combined models were 0.87, 0.96, and 0.99 in the training set UECT, and were 0.87, 0.97, and 0.98 in the training set CECT, respectively. The AUCs of the clinical, radiomics, and combined models were 0.84, 0.92, and 0.97 in the test set UECT, and were 0.84, 0.93, and 0.98 in the test set CECT, respectively. In regard to the differentiation between PSP and PC, the combined model was comparable to the radiomics model, but outperformed the clinical model and the two radiologists, whether in the test set UECT or CECT.ConclusionsRadiomics approaches show promise in distinguishing between PSP and PC. Moreover, the integration of clinical predictor (gender) has the potential to enhance the diagnostic performance even further.

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Peripheral pulmonary carcinoid tumor diagnosed by endobronchial‐ultrasound‐guided bronchoscopy

Tanaka

Akamatsu

Kawabata

et al. 2015

Respirology Case Reports

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A 45‐year‐old Japanese woman complained of uncontrolled hypertension and face swelling. She was diagnosed with Cushing's syndrome with secretion of adrenocorticotropic hormone. Fluorodeoxyglucose positron emission tomography‐computed tomography revealed a 2 × 2 cm mass in her left lung, with high standardized maximum uptake value. She underwent bronchoscopy with endobronchial ultrasound via a guide‐sheath. Surgical resection of her left upper lung was performed, and pathological examination showed a typical carcinoid tumor. After lung resection, she recovered from her subjective symptoms. Diagnosis of peripheral carcinoid tumor of the lung is generally difficult. Here, we introduce a case of peripheral pulmonary carcinoid tumor diagnosed by endobronchial‐ultrasound‐guided bronchoscopy.

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CT Features of Peripheral Pulmonary Carcinoid Tumors

Cited by 68 publications

References 17 publications

Endobronchial carcinoid tumor: Radiological findings of a clinical case

Endobronchial carcinoid tumor: Radiological findings of a clinical case

CT‐based radiomics for differentiating peripherally located pulmonary sclerosing pneumocytoma from carcinoid

Peripheral pulmonary carcinoid tumor diagnosed by endobronchial‐ultrasound‐guided bronchoscopy

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