CT features of parathyroid carcinomas: comparison with benign parathyroid lesions

Takumi, Koji; Fukukura, Yoshihiko; Hakamada, Hiroto; Nagano, Hiroaki; Kumagae, Yuichi; Arima, Hideo; Nakajo, Akihiro; Yamada, Takashi

doi:10.1007/s11604-019-00825-3

Cited by 12 publications

(23 citation statements)

References 25 publications

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“…In our study, there was no difference in the contrast enhancement and washout patterns between benign and malignant cohorts. This was in contrast to the previous study showing significantly poor arterial enhancement in the PC cohort 26 This may be attributed to the higher incidence of heterogeneity in the larger tumors in the benign sPHPT cohort resulting in decreased contrast enhancement 26 . Although, venous enhancement parameters were also nondiscriminatory in our study, a comparatively larger PC cohort is needed for a definite answer.…”

Section: Discussioncontrasting

confidence: 99%

“…Whereas, it was an additive factor to larger tumor diameter in multivariate analysis suggesting that larger and rounder tumors had higher chance of carcinoma than a larger and elliptical one. A similar overlap as an isolated parameter was described by Takumi et al 26 …”

Section: Discussionmentioning

confidence: 64%

“…Recently, contrast‐enhanced computed tomography (CECT) has emerged as a first‐line imaging modality for parathyroid localization due to higher sensitivity than other available modalities and lower radiation dose as compared to 99m Tc‐sestamibi SPECT/CT 21‐25 . But the data regarding CT characteristics of PC remain limited to two studies with small sample size 26,27 …”

Section: Introductionmentioning

confidence: 99%

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Preoperative prediction of parathyroid carcinoma in an Asian Indian cohort

et al. 2021

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Background Parathyroid carcinoma (PC) requires preoperative prediction for appropriate surgical management. Differentiation from symptomatic primary hyperparathyroidism (sPHPT) cohort is difficult. Methods Patients with sPHPT from a tertiary‐care center, Western India, including Cohort‐A (n = 19 [10/M; 9/F]) with PC and Cohort‐B (n = 93 [33/M; 60/F] with benign parathyroid lesions) were compared to derive predictors for differential diagnosis. Results There were no differences in clinical or biochemical parameters between the two cohorts. Comparison of CECT parameters showed that irregular shape, tumor heterogeneity, infiltration, short/long‐axis ratio >0.76, and long‐diameter >30 mm had high negative‐predictive value and intratumoral calcification had 100% positive‐predictive value to diagnose PC; whereas there were no differences in contrast‐enhancement patterns. Long diameter, short/long‐axis ratio, and heterogeneity were significant predictors on multivariate analysis. Conclusion It is difficult to predict diagnosis of PC in an Indian sPHPT cohort based on clinical and biochemical parameters, whereas CECT parathyroid‐based parameters can aid in diagnosis.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

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Preoperative prediction of parathyroid carcinoma in an Asian Indian cohort

et al. 2021

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“…CT and MRI scans are useful for detecting the parathyroid mass and invasion of surrounding tissues and for distant metastases. The CT features suggestive of malignancy are a high shortto-long axis ratio, irregular shape, the presence of peritumoral infiltration and calcification, and low contrast enhancement [50]. On MRI, all parathyroid lesions are very bright on fat saturated T2W images.…”

Section: Imaging Studiesmentioning

confidence: 99%

Parathyroid cancer: An update

Rodrigo

Hernández-Prera

Randolph

et al. 2020

Cancer Treatment Reviews

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…In most cases those methods are used in reop-REVIEW erative cases [30] and are helpful in early distinguishing of parathyroid carcinomas from other parathyroid lesions. Recent research showed that CT features of high short-to-long axis ratio, irregular shape, and the presence of peritumoral infiltration and calcification may be indicators for differentiating parathyroid carcinoma from benign parathyroid hyperplasia [31]. Radiation exposure to neck by 4D-CT is relatively high and its usage is limited to first investigation in order to diagnose of primary parathyroidism.…”

Section: Imaging Methodsmentioning

confidence: 99%

Primary hyperparathyroidism

Kowalski

Buła

Żądło

et al. 2020

Endokrynologia Polska

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Primary hyperparathyroidism is an endocrine disorder that results in overproduction of parathyroid hormone by overactivated parathyroid gland leading to a significant rise in blood serum calcium. It results in hypercalcaemia, which has a significant impact mainly on the kidneys and bones and results in a variety of signs and symptoms. Primary hyperparathyroidism should be treated because, if left without any therapy, it can lead even to death. Surgery is considered as the best and only successful therapy, with very low risk of recurrence and relatively low complication rate. The aim of this review is to present clinical basis, aetiology, diagnostic possibilities, and treatment opportunities.

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CT features of parathyroid carcinomas: comparison with benign parathyroid lesions

Cited by 12 publications

References 25 publications

Preoperative prediction of parathyroid carcinoma in an Asian Indian cohort

Preoperative prediction of parathyroid carcinoma in an Asian Indian cohort

Parathyroid cancer: An update

Primary hyperparathyroidism

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