CT Diagnosis of Dorsal Pancreas Agenesis

Shah, Kuldeep; DeRidder, Peter H.; Schwab, Richárd

doi:10.1097/00004728-198701000-00038

Cited by 33 publications

(8 citation statements)

References 0 publications

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“…Gold: Dorsal Pm)creas Agenesis, Pseudo-Agenesis similar to others reported with dorsal pancreatic agenesis [1,3], although the diabetes was adult rather than juvenile in onset. Like previously reported cases, this patient also presented with epigastric pain, although without exocrine pancreatic insufficiency.…”

Section: Discussionsupporting

confidence: 81%

“…One possible explanation is compensatory hypertrophy of the ventral anlage in response to the congenital loss of the rest of the gland. As emphasized by Shah et al [3], the ERCP appearance could mimic pancreas divisum in cases of dorsal agenesis. In the present case, however, the size and course of the pancreatic duct and the size of the gland stained with contrast suggested that this was not a typical divisum anomaly.…”

Section: Discussionmentioning

confidence: 86%

“…E The uncinate process remains intact. and a n n u l a r p a n c r e a s [2,3]. A g e n e s i s of the entire gland has b e e n r e p o r t e d o n c e and is i n c o m p a t i b l e with life [2].…”

Section: Discussionmentioning

confidence: 99%

“…A g e n e s i s of one of the p a n c r e a t i c b u d s is slightly m o r e frequent. A few r e p o r t s of a b s e n c e o f the d o r s a l p a n c r e a s h a v e a p p e a r e d [1][2][3], but only one c a s e of a p r o b a b l e a b s e n c e of the ventral pancreas [ 1]. R e c e n t l y , the s y n d r o m e o f p o l y s p l e n i a with a c o n g e n i t a l l y short p a n c r e a s has b e e n d e s c r i b e d in w h i c h the p a n c r e a t i c configuration was thought to r e p r e s e n t a g e n e s i s of the d o r s a l anlage [4].…”

Section: Discussionmentioning

confidence: 99%

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Agenesis and pseudo-agenesis of the dorsal pancreas

Gold

1993

Abdom Imaging

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Agenesis and pseudo-agenesis of the dorsal pancreas

Gold

1993

Abdom Imaging

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“…The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds in life, such as diabetes mellitus or pancreatitis (Gilinsky et al, 1985;Guntz et al, 1976;Gurson et al, 1970;Klein et al, 1994;Lechner and Read, 1966;Shah et al, 1987;Wang et al, 1990;Wildling et al, 1993). On the other hand, there are no reports of ventral pancreas agenesis.…”

Section: Introductionmentioning

confidence: 99%

The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds

et al. 2009

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During embryogenesis, the pancreas develops from separate dorsal and ventral buds, which fuse to form the mature pancreas. Little is known about the functional differences between these two buds or the relative contribution of cells derived from each region to the pancreas after fusion. To follow the fate of dorsal or ventral bud derived cells in the pancreas after fusion, we produced chimeric Elas-GFP transgenic/wild-type embryos in which either dorsal or ventral pancreatic bud cells expressed GFP. We found that ventral pancreatic cells migrate extensively into the dorsal pancreas after fusion, whereas the converse does not occur. Moreover, we found that annular pancreatic tissue is composed exclusively of ventral pancreas-derived cells. To identify ventral pancreas-specific genes that may play a role in pancreatic bud fusion, we isolated individual dorsal and ventral pancreatic buds, prior to fusion, from NF38/39 Xenopus laevis tadpoles and compared their gene expression profiles (NF refers to the specific stage of Xenopus development). As a result of this screen, we have identified several new ventral pancreas-specific genes, all of which are expressed in the same location within the ventral pancreas at the junction where the two ventral pancreatic buds fuse. Morpholinomediated knockdown of one of these ventral-specific genes, transmembrane 4 superfamily member 3 (tm4sf3), inhibited dorsalventral pancreatic bud fusion, as well as acinar cell differentiation. Conversely, overexpression of tm4sf3 promoted development of annular pancreas. Our results are the first to define molecular and behavioral differences between the dorsal and ventral pancreas, and suggest an unexpected role for the ventral pancreas in pancreatic bud fusion.

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