CT-Detected Growth of Coronary Artery Calcification in Asymptomatic Middle-Aged Subjects and Association With 15 Biomarkers

Diederichsen, Søren Zöga; Grønhøj, Mette Hjortdal; Mickley, Hans; Gerke, Oke; Steffensen, Flemming Hald; Lambrechtsen, Jess; Sand, Niels Peter Rønnow; Rasmussen, Lars Melholt; Olsen, Michael Hecht; Diederichsen, Axel Cosmus Pyndt

doi:10.1016/j.jcmg.2017.05.010

Cited by 45 publications

(58 citation statements)

References 38 publications

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“…Similar results have been reported by other studies. 21 , 22 Further analysis of the CS based on gender showed that the three subjects who had a CS >400 were males ( Table 2 ), buttressing the fact that coronary artery calcification is more prevalent in men compared to women. 16 , 17 , 19 However, the P -value observed for the distribution as shown in Table 2 indicates that there is not enough evidence to determine the effect of gender on the distribution of CAC.…”

Section: Discussionmentioning

confidence: 97%

“… 9 Dyslipidemia was defined as low levels of high-density lipoprotein cholesterol (men ≤1.036 mmol/L, women ≤1.295 mmol/L), high levels of low-density lipoprotein cholesterol (≥3.0 mmo/L) and/or hypertriglyceridemia ≥1.695 mmol/L. 10 , 22 Obesity/overweight was determined using the body mass index (BMI). The BMI was calculated as the weight of patients in kilograms divided by the square of the height in meters.…”

Section: Methodsmentioning

confidence: 99%

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Age–gender distribution of coronary artery calcium score in a black African population in Ghana

Frimpong

Owusu

Anyitey-Kokor

et al. 2018

VHRM

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BackgroundDistribution of coronary artery calcium (CAC) has been determined in different heterogeneous populations in the Multi-Ethnic Study of Atherosclerosis (MESA). Based on findings showing that geography and culture can influence CAC scoring beyond traditional race groups, we determined the distribution of CAC in a homogenous black African population to provide an initial basis for a larger CAC score study in Africa.Methods and resultsThis is a preliminary study using computed tomography to determine the CAC scores within a black African population who were referred to our center. Other information on patients were recorded through a combination of one-on-one interviews and medical records. A total of 170 patients were involved in our study, including 60.6% males, with an average age of 53.9 ± 9.2 years. The majority (78.8%) had a zero calcium score, with patients within the age group of 55–64 years dominating the non-zero calcium score population. Males were found to have higher calcium levels compared to females, and coronary artery calcification and prevalence steadily rose with the increasing age. However, P-values of 0.328 and <0.001 were observed with distribution of CAC according to gender and age, respectively.ConclusionFindings from this study showed that the distribution of CAC was markedly affected by the age of our study population, which will be more apparent in a larger study.

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Age–gender distribution of coronary artery calcium score in a black African population in Ghana

Frimpong

Owusu

Anyitey-Kokor

et al. 2018

VHRM

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“…In the Heinz Nixdorf Recall study, CAC inevitably progressed with limited influence of CV risk factors [ 19 ]. Diederichsen et al [ 20 ] recently evaluated the predictive value of 15 biomarkers for CAC incidence and progression in asymptomatic middle-aged subjects at 5 years follow-up. This prospective study identified the association between total and LDL cholesterol and CAC incidence, and between phosphate and CAC progression; however, 12 other biomarkers did not significantly correlate with CAC.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals

Won

Han

Lee

et al. 2018

Cardiovasc Diabetol

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BackgroundData on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited.MethodsData from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0–4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores.ResultsThe incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150–1.366) and diabetes (OR 2.471; 95% CI 2.215–2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group.ConclusionsIn asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, pre-diabetes did not increase the risk of CAC progression after adjusting for confounding factors.

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“…This rate of progression of CAC was modest compared with other studies of the progression of CAC on CCTA. 13,21,22,[26][27][28] In the Heinz Nixdorf Recall Study (HNRS), subjects 45-50 years of age had a mean Δ CAC progression of 38 Agatston units over a 5-year period. 21 In HNRS, authors reported that once the CAC process had begun, the progression of CAC followed an exponential trajectory.…”

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confidence: 99%

Endurance exercise training volume is not associated with progression of coronary artery calcification

Kleiven

Bjørkavoll-Bergseth

Omland

et al. 2020

Scandinavian Med Sci Sports

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Background:Recent cross-sectional studies have suggested a dose-dependent relationship between lifelong exposure to physical activity and the burden of calcified coronary artery disease (CAD). No longitudinal studies have addressed this concern. Hypothesis: Exercise volume is associated with progression of coronary artery calcium (CAC), defined as ≥10 units increase in CAC score. Methods: Sixty-one recreational athletes who were assessed by coronary computed tomography angiography (CCTA) as part of the NEEDED 2013/14 study were reassessed 4-5 years later, in 2018. Results: Subjects were 45.9 ± 9.6 years old at inclusion, and 46 (74%) were male.Between 2013 and 2018, the participants reported median 5 (range: 0-20, 25th-75th percentile: 4-6) hours of high-intensity exercise per week. None of the included subjects smoked during follow-up. At inclusion, 21 (33%) participants had coronary artery calcifications. On follow-up CCTA in 2018, 15 (25%) subjects had progressive coronary calcification (≥10 Agatston units increase in CAC). These subjects were older (53 ± 9 vs 44 ± 9 years old, P = .002) and had higher levels of low-density lipoprotein

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CT-Detected Growth of Coronary Artery Calcification in Asymptomatic Middle-Aged Subjects and Association With 15 Biomarkers

Cited by 45 publications

References 38 publications

Age–gender distribution of coronary artery calcium score in a black African population in Ghana

Age–gender distribution of coronary artery calcium score in a black African population in Ghana

Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals

Endurance exercise training volume is not associated with progression of coronary artery calcification

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CT-Detected Growth of Coronary Artery Calcification in Asymptomatic Middle-Aged Subjects and Association With 15 Biomarkers

Cited by 45 publications

References 38 publications

Age&ndash;gender distribution of coronary artery calcium score in a black African population in Ghana

Age&ndash;gender distribution of coronary artery calcium score in a black African population in Ghana

Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals

Endurance exercise training volume is not associated with progression of coronary artery calcification

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Age–gender distribution of coronary artery calcium score in a black African population in Ghana

Age–gender distribution of coronary artery calcium score in a black African population in Ghana