CT-based finite element simulating spatial bone damage accumulation predicts metastatic human vertebrae strength and stiffness
Zahra Soltani,
Michelle Xu,
Raul Radovitzky
et al.
Abstract:Introduction: Pathologic vertebral fractures are devastating for patients with spinal metastases. However, the mechanical process underlying these fractures is poorly understood, limiting physician’s ability to predict which vertebral bodies will fail.Method: Here, we show the development of a damage-based finite element framework producing highly reliable pathologic vertebral strength and stiffness predictions from X-Ray computed tomography (CT) data. We evaluated the performance of specimen-specific material… Show more
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