CT-assisted assessment of bladder and rectum dose in gynecological implants

Ling, C. Clifton; Schell, Michael C.; Jentzsch, K.; Harisiadis, Leon; Carabell, Steven C.; Rogers, Charles C.

doi:10.1016/0360-3016(87)90327-0

Cited by 123 publications

(43 citation statements)

References 21 publications

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“…However, these points are not the best surrogates. Many studies have reported inconsistencies between these points compared with volumetric image-based 3D dose calculation and they cannot be the best estimate to predict late complication to organs at risk (Ling et al, 1987;Schoeppel et al, 1993;Barillot et al, 1994;van der Bergh et al, 1998;Fellner et al, 2001;Jason et al, 2003;Kirisits et al, 2005;Pelloski et al, 2005;Tan et al, 2009;Vinod et al, 2011). Imagebased brachytherapy allows more conformal treatment, integrating the concepts of anatomy, tumour features, and tumour response with time.…”

Section: Discussionmentioning

confidence: 99%

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

Hashim¹,

Jamalludin²,

Ung³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

Hashim¹,

Jamalludin²,

Ung³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Point dosing can also lead to excessive normal tissue toxicity, as with smaller tumors and smaller uteri in which predefined points may deliver dose into the bladder or rectum. Conventional International Commission on Radiation Units and Measurements (ICRU) points have been shown in several studies to underestimate maximum doses to the bladder and rectum (3,(5)(6)(7)(8)(9)(10)(11), and doses to these points have often failed to correlate with late toxicity (12). This may in part explain the relatively high rates of severe late gastrointestinal (GI) and genitourinary (GU) toxicity in the range of 5% to 10% reported in previous studies of conventional treatment techniques (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of Computed Tomography–Based Volumetric Brachytherapy Planning for Cervical Cancer

Simpson¹,

Scanderbeg²,

Carmona³

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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SummaryImage guided brachytherapy (IGBT) has been adopted by multiple centers in recent years for the treatment of cervical cancer. The clinical outcomes are promising, with favorable results compared with those of conventional techniques. Previously reported studies have used primarily magnetic resonance imagingdbased treatment planning. We report the clinical outcomes of a novel hybrid computed tomographyebased IGBT technique. At 2 years, local control was excellent, with low rates of treatment toxicity. Further Purpose/Objectives: A report of clinical outcomes of a computed tomography (CT)-based image guided brachytherapy (IGBT) technique for treatment of cervical cancer. Methods and Materials: Seventy-six women with International Federation of Gynecology and Obstetrics stage IB to IVA cervical carcinoma diagnosed between 2007 and 2014 were treated with definitive external beam radiation therapy (EBRT) with or without concurrent chemotherapy followed by high-dose-rate (HDR) IGBT. All patients underwent planning CT simulation at each implantation. A high-risk clinical target volume (HRCTV) encompassing any visible tumor and the entire cervix was contoured on the simulation CT. When available, magnetic resonance imaging (MRI) was performed at implantation to assist with tumor delineation. The prescription dose was prescribed to the HRCTV. Results: The median follow-up time was 17 months. Thirteen patients (17%) had an MRI done before brachytherapy, and 16 patients (21%) were treated without MRI guidance. The mean EBRT/IGBT sum 2-Gy equivalent dose (EQD2) delivered to the 90% volume of the HRCTV was 86.3 Gy. The mean maximum EQD2s delivered to 2 cm 3 of the rectum, sigmoid, and bladder were 67.5 Gy, 66.2 Gy, and 75.3 Gy, respectively. The 2-year cumulative incidences of local, locoregional, and distant failure were 5.8% (95% confidence interval [CI]: 1.4%-14.8%), 15.1% (95% CI: 5.4%-29.4%), and 24.3% (95% CI: 12.1%-38.9%), respectively. The 2-year overall and disease-free survival rates were 75% (95% CI, 61%-91%) and 73% (95% CI, 60%-90%), respectively. Twenty-nine patients (38%) experienced grade !2 acute toxicity, with 5 cases of acute grade 3 toxicity and no grade !4 toxicities. One

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“…Compared with the more recent 3D planning techniques, 2D planning generally overestimates the minimum dose delivered to the target volume and underestimates the maximum dose to the normal tissues. 12,[32][33][34] Consequently, reliable estimates of doses to the rectum for predicting the risk of LRC have not been established to date, and further larger scale studies and careful analyses of dose-volume histograms are required. However, the effectiveness of the absorbed dose at the RP, as defined by ICRU 38, has been demonstrated in other reports, with correlations between the dose estimates at the RP (BED RP ) and the risk of LRC being identified.…”

Section: Discussionmentioning

confidence: 99%

Dosimetric parameters that predict late rectal complications after curative radiotherapy in patients with uterine cervical carcinoma

Kim

Choi

Park

et al. 2005

Cancer

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Expertise‐seeking research studies how people search for expertise and choose whom to contact in the context of a specific task. An important outcome are models that identify factors that influence expert finding. Expertise retrieval addresses the same problem, expert finding, but from a system‐centered perspective. The main focus has been on developing content‐based algorithms similar to document search. These algorithms identify matching experts primarily on the basis of the textual content of documents with which experts are associated. Other factors, such as the ones identified by expertise‐seeking models, are rarely taken into account. In this article, we extend content‐based expert‐finding approaches with contextual factors that have been found to influence human expert finding. We focus on a task of science communicators in a knowledge‐intensive environment, the task of finding similar experts, given an example expert. Our approach combines expertise‐seeking and retrieval research. First, we conduct a user study to identify contextual factors that may play a role in the studied task and environment. Then, we design expert retrieval models to capture these factors. We combine these with content‐based retrieval models and evaluate them in a retrieval experiment. Our main finding is that while content‐based features are the most important, human participants also take contextual factors into account, such as media experience and organizational structure. We develop two principled ways of modeling the identified factors and integrate them with content‐based retrieval models. Our experiments show that models combining content‐based and contextual factors can significantly outperform existing content‐based models.

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CT-assisted assessment of bladder and rectum dose in gynecological implants

Cited by 123 publications

References 21 publications

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

Clinical Outcomes of Computed Tomography–Based Volumetric Brachytherapy Planning for Cervical Cancer

Dosimetric parameters that predict late rectal complications after curative radiotherapy in patients with uterine cervical carcinoma

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