CT Assessment of Subtypes of Pulmonary Emphysema in Smokers

Satoh, Katashi; Kobayashi, Takuya; Misao, Takahiko; Hitani, Yoshimi; Yamamoto, Yuka; Nishiyama, Yoshihiro; Ohkawa, Motoomi

doi:10.1378/chest.120.3.725

Cited by 58 publications

(45 citation statements)

References 11 publications

(9 reference statements)

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“…In spite of previous opinions, paraseptal emphysema may also be smoking related [14,17]. Our study revealed that 43% of the smokers had predominantly paraseptal emphysema.…”

Section: Limitations and Strengthcontrasting

confidence: 92%

High prevalence of emphysema and its association with BMI: A study of smokers with normal spirometry

Stratelis

Fransson

Schmekel

et al. 2008

Scandinavian Journal of Primary Health Care

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“…In spite of previous opinions, paraseptal emphysema may also be smoking related [14,17]. Our study revealed that 43% of the smokers had predominantly paraseptal emphysema.…”

Section: Limitations and Strengthcontrasting

confidence: 92%

High prevalence of emphysema and its association with BMI: A study of smokers with normal spirometry

Stratelis

Fransson

Schmekel

et al. 2008

Scandinavian Journal of Primary Health Care

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“…PSE is characterized at CT by subpleural and peribronchovascular foci of low attenuation separated by intact interlobular septa thickened by associated mild fibrosis (78) (Figs 8, 9). PSE has a special predilection for peripheral subpleural lobules along the mediastinal and peripheral pleura and fissures, usually most marked in the middle and upper lungs and along the mediastinum.…”

Section: Paraseptal Emphysemamentioning

confidence: 99%

CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society

Lynch¹,

Austin²,

Hogg³

et al. 2015

Radiology

472

413

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“…Although tobacco smoking has been identified as a major cause, the exact pathophysiology of the CPFE syndrome is unclear [20,21]. Possible additional risk factors have been identified, such as exposure to agrochemical compounds [22].…”

Section: Pathology and Pathogenesismentioning

confidence: 99%

The impact of emphysema in pulmonary fibrosis

Cottin¹

2013

Eur Respir Rev

131

115

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Several groups have described a syndrome in which idiopathic pulmonary fibrosis (IPF) coexists with pulmonary emphysema. This comes as no surprise since both diseases are associated with a history of exposure to cigarette smoke. The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterised by upper lobe emphysema and lower lobe fibrosis. Physiological testing of these patients reveals preserved lung volume indices contrasted by markedly impaired diffusion capacity. The incidence of CPFE remains unknown but several case series suggest that this subgroup may comprise up to 35% of patients with IPF. CPFE is a strong determinant of associated pulmonary hypertension (PH). In addition, CPFE has major effects on measures of physiological function, exercise capacity and prognosis, and may affect the results of pulmonary fibrosis trials. Further studies are needed to ascertain the aetiology, morbidity, mortality and management of the CPFE syndrome, with or without PH, and to evaluate novel therapeutic options in CPFE.

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CT Assessment of Subtypes of Pulmonary Emphysema in Smokers

Cited by 58 publications

References 11 publications

High prevalence of emphysema and its association with BMI: A study of smokers with normal spirometry

High prevalence of emphysema and its association with BMI: A study of smokers with normal spirometry

CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society

The impact of emphysema in pulmonary fibrosis

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