CT appearance of Varicella Zoster lesions in liver and spleen in an immunocompetent patient

Fatal varicella in an immunocompromised adult associated with a European genotype E2 variant of varicella zoster virus

“…Persistent detection of VZV DNA and lesions in liver and spleen have been described previously. 2,3 The disease is often more severe in adults than in children, with more prominent rash, fever and interstitial pneumonitis. Bleeding abnormalities, including increased capillary fragility, disseminated intravascular coagulation, and thrombocytopenia, may also occur.…”

Hepatitis and a rash in an immunocompromised patient

“…The patient was immunocompromised and died of multi-organ failure soon after the CT. In the other report [3] an immunocompetent patient responded to aciclovir therapy and a follow-up study showed resolution of the liver lesions. Our report, therefore, is only the second imaging description of VZV hepatitis, which responded to appropriate antiviral therapy.…”

“…The blood test results confirmed a lymphopaenia 0. 3 ). Hepatitis virus antibodies (hepatitis B and C) and antibody markers of autoimmune diseases were all negative.…”

A rare case of disseminated shingles in an immunocompetent patient following a 7-day treatment with oral valacyclovir

“…8 The average age for disseminated herpes zoster in reported immunocompetent patients is 65.4 years. 7,9,10 The signs and symptoms resolved in three out of five of the patients with oral acyclovir, while the others were given IV dosing. 7,9,10 At the age of 39, our patient is significantly younger than the average reported age of disseminated zoster in immunocompetent patients, indicating that he is not likely to have the age-related decline of VZV-specific T cell immunity that is characteristic of advanced age, and his dissemination occurred after completion of antiviral therapy.…”