CT and PET/CT Findings of T-Cell Lymphoma

Abstract

The extranodal features of T-cell lymphoma are not specific and usually cannot be used to differentiate T-cell lymphoma from other aggressive types of lymphoma. Noncutaneous subtypes frequently manifest with visceral involvement. The goal of CT in initial staging is to exclude visceral involvement. Evidence on the utility of PET/CT is promising, showing high diagnostic value in evaluation of occult disease and treatment response, but the role of PET/CT is evolving.

Prognostic Value of Interim and Posttherapy 18F-FDG PET/CT in Patients with Mature T-Cell and Natural Killer Cell Lymphomas

“…In the present study, a positive interim PET/CT result was found to be significantly correlated with inferior PFS and OS in T/NK-cell lymphomas, confirming the findings of Choi et al but not the findings of Cahu et al and Pro et al (17)(18)(19). Some technical differences studies may explain this discrepancy.…”

“…Second, patients in the study by Cahu et al were recruited from 5 independent institutions with different PET systems and protocols, possibly leading to heterogeneity in the results of PET. In addition, the sample size in our study was larger (n 5 62 vs. n # 35) (17)(18)(19). More important, our study showed a higher PPV of interim PET/CT (77.9% vs. 39%), meaning a high incidence of relapse or progression among patients with positive results at interim PET/CT.…”

“…The prognostic role of early 18 F-FDG PET in DLBCL and HL has been widely confirmed by numerous studies (4-8); however, studies focusing on the prognostic value of interim or posttherapy 18 F-FDG PET in T/NK-cell lymphomas are indeed rare and the results are contradictory (17)(18)(19). In the present study, the prognostic value of interim and posttherapy PET/CT was assessed in a series of patients with T/NK-cell lymphomas.…”

F-18 flourodeoxyglucose positron emission tomography/computed tomography findings in a case of hepatosplenic T-cell lymphoma

“…In hepatosplenic TCL, hepatosplenomegaly is seen at CT and is typically the only imaging finding. [4,5] The described case had similar findings on CT.…”

“…[4,6] Use of FDG PET/CT in cutaneous and subcutaneous panniculitislike TCL suggests that it outperforms physical examination in evaluation for subcutaneous lesions. In addition, PET/CT can be used to monitor the response to therapy of lymph nodes that are FDG-avid but do not meet the size criteria for staging (< 1 cm).…”