CT- and MRI-Aided Fluorescence Tomography Reconstructions for Biodistribution Analysis
Sarah Schraven,
Ramona Brück,
Stefanie Rosenhain
et al.
Abstract:Objectives
Optical fluorescence imaging can track the biodistribution of fluorophore-labeled drugs, nanoparticles, and antibodies longitudinally. In hybrid computed tomography–fluorescence tomography (CT-FLT), CT provides the anatomical information to generate scattering and absorption maps supporting a 3-dimensional reconstruction from the raw optical data. However, given the CT's limited soft tissue contrast, fluorescence reconstruction and quantification can be inaccurate and not sufficiently de… Show more
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