CT and MR imaging of cerebral tuberous sclerosis

Inoue, Yuichi; Nemoto, Y; Murata, Ryousuke; Tashiro, Takahiko; Shakudo, M; Kohno, Kinuko; Matsuoka, Osamu; Mochizuki, K

doi:10.1016/s0387-7604(98)00022-9

Cited by 59 publications

(49 citation statements)

References 35 publications

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“…TSC derives its name from cortical tubers, so called for their gross pathologic "potatolike" appearance (9). They occur in as many as 95% of patients (3,17). Tubers most commonly involve surface cortical and…”

Section: Cardiac Renal and Eye Findingsmentioning

confidence: 99%

“…Their architecture expands the gyri and disrupts the graywhite matter junction. Tubers vary in size from millimeters to centimeters and are frequently multiple (4,10,17,19,27).…”

Section: A B C Ekici Ma Et Al: Surgical Timing Of the Subependymal Gmentioning

confidence: 99%

“…SENs are most commonly found around the area of the foramen Monro. They tend to calcify with time and for this reason are often more easily identified on CT imaging (1,4,16,17,27). Literature proposes that subependymal nodules a turn into tumor as a risk factor when they are greater than 5mm, with incomplete calcification and contrast enhancement.…”

Section: A B C Ekici Ma Et Al: Surgical Timing Of the Subependymal Gmentioning

confidence: 99%

“…In children, 110 cases of subependymal giant cell astrocytomas have been reported in the literature. They were usually discovered after 10 years, at a mean age of 13 years (5,9,16,17,20,22 (14,26,27). After the renal USG, performed to the patients, angiomyolipoma was detected in the 14 of the patients (37,8%).…”

Section: A B C Ekici Ma Et Al: Surgical Timing Of the Subependymal Gmentioning

confidence: 99%

“…The classic TSC central nervous system findings of cortical tubers, subependymal nodules (SENs), subependymal giantcell astrocytomas (SEGAs), and white-matter abnormalities are now easily identified by modern neuroimaging techniques (3,4,17,19,20). SEGAs are benign tumors that occur in approximately 10% of patients with TSC.…”

Section: Introductionmentioning

confidence: 99%

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Surgical timing of the subependymal giant cell astrocytoma (sega) with the patients of tuberous sclerosis complex. .

Ekici

Kumandaş²,

Per³

et al. 2011

Turkish Neurosurgery

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AIm: Tuberous sclerosis complex has shown a wide variety of clinical, pathologic and radiologic manifestations. Many tumor types are found in tuberous sclerosis, which includes subependimal giant cell astrositoma. The aim of this study is to focus on surgical timing of the tumor. mAterIAl and methOds: This study included 37 children with tuberous sclerosis presenting to Erciyes Univercity Medical School, whose hospital record were retrospectively evaluated between 1995 and 2010. Of the 5 patients had diagnosed with the subependymal giant cell astrocytoma and three patients were opereted on.results: In the 27 of the patients had subependimal nodules (73%), cortical tubers were in the 19 patients (51,4%), giant cell astrositoma (SEGA) were in the 5 patients (13,5%). Mental retardation in different level was detected in the 18 patients (48.6%). The other clinical findings of the patients were angiomyolipomas (37.8%), hypomelanotic macules (91.9%), Convulsion (54.1%), adenoma sebaceum (32.4%) , West syndrome (16.22%), shagreeen patch (16.2%), intracardiac tumor (37.8%), subungual fibroma (2.7%), fibroadenom in the neck (2.7%).COnClusIOn: A multidisciplinary approach is essential for an early, accurate diagnosis and proper management of affected individuals. The early surgical menagement for subependimal giant cell astrocytoma are recommended, and also periodic monitoring even for asymptomatic patients with subependymal nodules. KeywOrds: Tuberous sclerosis complex, Subependymal giant cell astrositoma, Surgical timing ÖZAmAÇ: Tüberus sklerozis kompleks klinik, patolojik ve radyolojikolarak geniş bir çeşitlilik göstermektedir. Subependimal dev hücreli astrositomanın dahil olduğu birçok tümör tipi bulunur. Bu çalışmanın amacı tümörün cerrahi zamanlamasına dikkat çekmek. yÖntem ve GereÇ: Erciyes Üniversitesi Tıp Fakültesi Hastanesi'nde 1995-2010 yılları arasında hasta kayıtları geriye dönük olarak değerlen-dirildi ve 37 tüberus sklerozisli hasta çalışmaya dahil edildi. Hastaların 5'ine subependimal dev hücreli astrositom tanısı konuldu ve üç hasta ameliyat edildi.BulGulAr: 27 hastada (%73) subependimal nodul, 19 hastada (%51.4) kortikal tuber, 5 hastada (%13.5) dev hücreli astrositom vardı. 18 hastada (%48.6) farklı seviyelerde mental retardasyon tespit edildi. Hastaların diğer klinik bulguları; anjiyomyolipom (%37.8), hipomelanotik makul (%91.9), konvulzyon (%54.1), adenoma sebaseum (%32.4), west sendromu (%16.2), shagreen lekeleri (%16.2), intrakardiak tümör (%37.8), subungual fibroma (%2.7), boyunda fibro adenomdu (%2.7).sOnuÇ: Etkilenmiş bireylerin erken, doğru ve uygun tedavisi için multidisipliner yaklaşım esastır. Subependimal dev hücreli astrositomada erken cerrahi önerilir ve de subependimal nodullü hastalar için peryodik izleme önerilir.AnAhtAr sÖZCÜKler: Tüberus sklerozis kompleks, Subependimal dev hücreli astrositom, Cerrahi zamanlama

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Section: Cardiac Renal and Eye Findingsmentioning

confidence: 99%

“…Their architecture expands the gyri and disrupts the graywhite matter junction. Tubers vary in size from millimeters to centimeters and are frequently multiple (4,10,17,19,27).…”

Section: A B C Ekici Ma Et Al: Surgical Timing Of the Subependymal Gmentioning

confidence: 99%