CSPG4-dependent cytotoxicity for
C. difficile
TcdB is influenced by extracellular calcium and chondroitin sulfate
D. Annie Doyle,
Paul L. DeAngelis,
Jimmy D. Ballard
Abstract:TcdB is an intracellular bacterial toxin indispensable to
Clostridioides difficile
infections. The ability to use chondroitin sulfate proteoglycan 4 (CSPG4) as a primary cell surface receptor is evolutionarily conserved by the two major variants of TcdB. As CSPG4 does not typically undergo receptor-mediated endocytosis, we sought to identify environmental factors that stabilize interactions between TcdB and CSPG4 to promote cell binding and entry into the cytosol. Using a series of … Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.