CSK-Homologous Kinase

Abstract

Crk SH3 domain binding guanine nucleotide release protein (C3G), Rap guanine nucleotide exchange factor 1 (RAPGEF1), Guanine nucleotide-releasing factor 2 (GRF2) 620 C3G 622 C3G C3G 623 C Downregulated Fernandez et al. 2008 Lymphoproliferative disorder Mutation, Y572C Parker et al. 2016 Human prostate carcinoma Regulates PLCg1-mediated adhesion Peak et al. 2008 Juvenile neuronal ceroid lipofuscinosis Upregulated Lebrun et al. 2011 624 C3G fate determinant. While its catalytic activity enables activation of small GTPases of Ras family, it also has cellular roles independent of its catalytic activity. The fact that other Rap1 GEFs do not compliment C3G during mammalian embryonic development suggests important noncatalytic functions, or its ability to activate other GTPases. Recent studies have shown that altered C3G levels are associated with human cancers and other disorders, suggesting its role in maintaining homeostasis in adult tissues.