CSFs regulate basophil function

Hirai, Koichi; Morita, Yutaka; Misaki, Yoshikata; Ohta, Kunihiro; Suzuki, Sh.; Miyamoto, Tomofumi

doi:10.1016/0192-0561(88)90310-4

Cited by 17 publications

(31 citation statements)

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“…We also examined the effect of rhIL-2, rhIL-3, and rhGM-CSF on IgE-mediated histamine release from normal donors' blood basophils. Our results show that basophils are activated by rhIL-3 and rhGM-CSF (but not rhIL-2) for increased histamine releasability, which confirms the data obtained by Hirai et al (13). The exact mechanism for this increased response of normal blood basophils to anti-IgE antibodies caused by rhIL-3 and rhGM-CSF remains unknown.…”

supporting

confidence: 81%

“…Whereas Haak-Frendscho et al (12) described histamine release from blood basophils in direct response to recombinant human IL-3 (rhIL-3) as well as recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF), no direct histamine-releasing activity of these cytokines was found in our own experiments (14). More recently, Hirai et al (13) reported that the histamine release from normal blood basophils induced by various stimuli such as anti-IgE antibodies could be enhanced by preincubation of basophils with rhIL-3 or rhGM-CSF. However, the mechanisms by which rhIL-3 and rhGM-CSF stimulate human blood basophils remain unclear.…”

mentioning

confidence: 99%

“…Most significantly, IgE molecules mediate basophil histamine release via specific surface membrane receptors (2)(3)(4)(5). Recent data suggest that T-cell activation products regulate growth and function of human basophils (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Interleukin 3 (IL-3), a multipotential lymphokine, has been shown to support differentiation of human basophils from their precursors in bone marrow and cord blood (14)(15)(16).…”

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confidence: 99%

“…Interleukin 3 (IL-3), a multipotential lymphokine, has been shown to support differentiation of human basophils from their precursors in bone marrow and cord blood (14)(15)(16). Reports on a potential role for IL-3 in regulating histamine release from human blood basophils have been controversial (12)(13)(14). Whereas Haak-Frendscho et al (12) described histamine release from blood basophils in direct response to recombinant human IL-3 (rhIL-3) as well as recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF), no direct histamine-releasing activity of these cytokines was found in our own experiments (14).…”

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confidence: 99%

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Interleukin 3 activates human blood basophils via high-affinity binding sites.

Valent

Besemer

Muhm

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

191

166

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Pure populations of human basophilic granulocytes were obtained from chronic myeloid leukemia (CML) blood by negative selection using a mixture of monoclonal antibodies and complement. '25Iradiolabeled recombinant human interleukin 3 (rhIL-3) bound to purified basophils in a specific manner. Quantitative binding studies and Scatchard plot analyses performed on samples from two donors revealed the presence of a single class of high-affinity IL-3 binding sites (500 and 2100 sites per cell; dissociation constant at equilibrium, 230 and 160 pmol/liter, respectively). Purified CML basophils maintained in suspension in the presence of rhIL-3 (100 units/ml) incorporated up to 12 times more [Hlthymidine than basophils in control cultures. Furthermore, after preincubation in vitro with rhIL-3 (100 units/mi) for 30 min, normal blood basophils released 2-to 3-fold more histamine than basophils pretreated with control medium when exposed to various concentrations ofan anti-IgE antibody. Together, these results show that rhIL-3 binds to a specific receptor on blood basophils and is a regulator of basophil function.

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confidence: 81%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Interleukin 3 activates human blood basophils via high-affinity binding sites.

Valent

Besemer

Muhm

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

191

166

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“…[1][2][3][4][5][6] Up to now, many publications in the open literature have been found in synthesis of production of pyromellitic dianhydride (PMDA), and the classical method for such a synthesis constitutes the liquid-phase oxidation of 1,2,4,5-tetraalkyl benzene catalyzed by cobalt, manganese, bromine, nitric acid or dichromic acid in the presence of 100-450 psig, and then dehydrating the obtained pyromellitic acid into pyromellitic dianhydride. [7][8][9][10] However, this procedure is invariably associated with certain limitations such as high cost, long reaction time, environmental hazards, special apparatus and drastic reaction conditions. The catalytic vapor-phase oxidation of 1,2,4,5-tetraalkyl benzene under oxyen pressure using a certain catalyst (e.g.…”

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confidence: 99%

An inexpensive and efficient synthetic method for the preparation of pyromellitic dianhyride in ionic liquid

Lu¹,

Lin²,

Liu³

et al. 2010

Arkivoc

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In this article, pyromellitic dianhydride could be successfully obtained in 76.7% total yield by an aerobic oxidation of 1,4-bis(chloromethyl)-2,5-dimethylbenzene or 1,5-bis(chloromethyl)-2,4-dimethylbenzene catalyzed by VO(acac) 2 /Cu(2-Eth) 2 /DABCO in [hmim]OTf and a subsequent dehydration of pyromellitic acid upon heating with acetic anhydride. The starting materials including 1,2-bis(chloromethyl)-4,5-dimethylbenzene were prepared by dichloromethylation of their corresponding xylene catalyzed by [C 12 mim]Br in aqueous media.

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Outcomes of Patients 65 Years or Older After Out-of-Hospital Cardiac Arrest Based on Location of Cardiac Arrest in Japan

et al. 2019

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Key Points Question Do the characteristics and outcomes of out-of-hospital cardiac arrest among patients aged 65 years or older differ by the location where the arrest occurs (public, residential, or nursing home) in Japan? Findings In this Japanese nationwide, population-based cohort study of 233 511 persons 65 years or older, the incidence of and the demographic and clinical characteristics of the patients and their outcomes following out-of-hospital cardiac arrest differed according to the location of the arrest. However, the differences in outcomes among patients based on location decreased with age. Meaning These results support implementing improved resuscitation strategies for persons experiencing out-of-hospital cardiac arrest in other industrialized countries.

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CSFs regulate basophil function

Cited by 17 publications

References 0 publications

Interleukin 3 activates human blood basophils via high-affinity binding sites.

Interleukin 3 activates human blood basophils via high-affinity binding sites.

An inexpensive and efficient synthetic method for the preparation of pyromellitic dianhyride in ionic liquid

Outcomes of Patients 65 Years or Older After Out-of-Hospital Cardiac Arrest Based on Location of Cardiac Arrest in Japan

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