CSF Shunt Infections in Pediatrics

Odio, Carla

doi:10.1001/archpedi.1984.02140500009004

Cited by 197 publications

(97 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most common complication is shunt infection. Shunt-related deaths account for onethird of all deaths due to shunt infection (20). This study evaluated the medical and economic aspects of VPS-related infections in children at our hospital.…”

Section: Discussionmentioning

confidence: 99%

“…The exclusion criteria were VPSI before the study period, a history of a shunt operation in another center, and a lack of medical records. The criteria for a diagnosis of CSF shunt infection were as follows: a positive CSF culture, CSF findings consistent with infection (leukocyte count of >50/mm 3 or glucose ratio [CSF glucose/serum glucose] of <0.4) associated with fever [temperature of >38.5°C]), shunt malfunction, or neurological symptoms (17,20,27). Burr-hole type shunts were placed in all patients with medium pressure adjustment (70-110 mmH 2 O), and cefazolin sodium prophylaxis was intravenously administered before the skin incision (25 mg/kg); two doses were repeated within 24h after the surgery (12,21).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Clinic and economic results of the ventriculoperitoneal shunt infections in children

Kanık¹,

Sirin²,

Köse³

et al. 2014

Turkish Neurosurgery

View full text Add to dashboard Cite

AIm: This study evaluated the clinical and economic outcomes of ventriculoperitoneal shunt infections. mATErIAl and mEThOds:Patients diagnosed with ventriculoperitoneal shunt infections for the first time between 1 January 2007 and 31 December 2011 were included in this study. Demographic, clinical, and economic data were analyzed retrospectively. A cost coefficient (total cost/follow-up period) and hospitalization coefficient (duration of hospitalization/follow-up period) were calculated for each patient. rEsulTs:In total, 132 shunt infections (mean follow-up, 734 ± 367 days) were evaluated in 51 patients (mean age, 16.6 ± 9.22 months; median age, 3 months; range, 1-88 months; 28 females, 21 males). In 23 patients (45%), shunt infections were seen in the first 2 months following shunt placement. Seven patients died during the follow-up. There was a negative correlation between the age at diagnosis and the hospitalization duration (p = 0.005, r = -0.381). The average cost of hospitalization per patient was 6397 ± 4338 TL. There was a negative correlation between the cost index and the age at diagnosis (p = 0.04, r = -0.292).CONClusION: Ventriculoperitoneal shunt infections have significant medical and economic impacts. Younger the diagnosis of patients, the hospitalization duration and treatment cost were higher. BulGulAr: Toplam 51 olgudaki (ortalama yaş: 2,58±1,75 ay; ortanca yaş: 3 ay: dağılım aralığı: 1-88 ay; 28 kız / 21 erkek) 132 şant enfeksiyonu (ortalama izlem süresi: 734± 367 gün) değerlendirilmeye alındı. Olguların 23'ünde (%45) ilk enfeksiyon şantın takılmasından sonraki ilk 2 ayda ortaya çıktı. Toplam yedi hasta izlemde kaybedildi. Olguların tanı yaşları ile yatış süresi katsayıları arasında negatif yönde anlamlı bir korelasyon olduğu görüldü (p=0,005; r = -0,381). Bir hasta için yatış başına düşen ortalama maliyet 6397±4338 TL olarak hesaplandı. Bu hastaların maliyet katsayısı ile tanı yaşı arasında negatif yönde anlamlı bir korelasyon saptandı (p=0,04; r = -0,292). sONuÇ: Ventriküloperitoneal şant enfeksiyonları ciddi tıbbi ve ekonomik sonuçlara neden olmaktadır. Hastaların tanı yaşı küçüldükçe hastanede yatış süreleri ve tedavi maliyetleri artmaktadır.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Clinic and economic results of the ventriculoperitoneal shunt infections in children

Kanık¹,

Sirin²,

Köse³

et al. 2014

Turkish Neurosurgery

View full text Add to dashboard Cite

show abstract

“…Staphylococcus aureus; for ventriculoperitoneal shunts pathogens orginate from the enteric system with gramnegative bacilli [12,13]. Thus, the prevailing hypothesis for CSF shunt infection is that the infecting organism is introduced during surgical manipulation of the site.…”

mentioning

confidence: 99%

“…Investigators have noted considerable variation in treatment duration and methods of medical and surgical management of shunt infections that might explain reinfections [11,12,16,17]. Development of a second CSF shunt infection is a particularly critical event because it is associated with recurrent reinfections in a small number of children [18].…”

mentioning

confidence: 99%

Few Patient, Treatment, and Diagnostic or Microbiological Factors, Except Complications and Intermittent Negative Cerebrospinal Fluid (CSF) Cultures During First CSF Shunt Infection, Are Associated With Reinfection

Simon¹,

Mayer-Hamblett²,

Whitlock³

et al. 2013

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

Background. The relationship between first and subsequent cerebrospinal fluid (CSF) shunt infections is poorly understood. By understanding the factors associated with increased risk of reinfection, researchers may provide optimal treatment strategies at the time of first infection. The objective of this study was to describe and compare children with and without CSF shunt reinfection. Methods. A retrospective cohort study was performed among 118 children who underwent initial CSF shunt placement and developed first CSF shunt infection. The primary outcome variable was CSF shunt reinfection. Patient risk factors and medical and surgical management of initial CSF shunt placement and first CSF shunt infection were compared between children with and without reinfection. Results. Of 118 children with first infection, 31 (26%) developed a reinfection during the study period (overall median follow-up, 2096 days). Factors associated with reinfection in this cohort included ventriculoatrial or complex shunt at initial CSF shunt placement, complications after first CSF shunt infection, and intermittent negative CSF cultures. Conclusions. Few patient or treatment factors were associated with reinfection. Factors associated with difficult-to-treat first CSF shunt infection, including complications after first CSF shunt infection and intermittent negative CSF cultures, were associated with reinfection. Clinicians who treat patients with unusual CSF shunts or more difficult first infections should have a high index of suspicion for reinfection after treatment is completed.

show abstract

“…Similar results were obtained in a retrospective study conducted in Switzerland and Canada, whereas some other studies related to pediatric CSF reported Staphylococcus spp. as the most common cause of infection (75%) 11 . MRSA isolated from prosthetic devices showed a 67% resistance to amikacin and 87% resistance to gentamycin; these results disagreed with those of a previous study.…”

mentioning

confidence: 99%

Prevalence and antibiogram of methicillin resistant Staphylococcus aureus isolated from medical device-related infections; a retrospective study in Lahore, Pakistan

Sohail

Latif

2017

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: With the advancement of medicine and surgery, various types of medical devices have become part of treatment strategies. Methods: Identification and antimicrobial sensitivity testing were done according to CLSI guidelines following standard microbiological practices. Results: Urinary catheter infections (31%) were most frequent followed by central venous catheter (18%) and orthopedic implants (15%). Methicillin resistant Staphylococcus aureus (MRSA) was a major cause of device-related infection after Escherichia coli (21%); other pathogens were Klebsiella pneumoniae (14%), Pseudomonas spp. (10%), Acinetobacter spp. (8%) and Candida species (7%). None of MRSA was resistant to vancomycin (MIC ≥16µg/mL). Resistance rates were 98% and 97% for ofloxacin and ciprofloxacin, respectively. Conclusions: Escherichia coli and MRSA are major pathogens of medical device-related infections.

show abstract

CSF Shunt Infections in Pediatrics

Cited by 197 publications

References 17 publications

Clinic and economic results of the ventriculoperitoneal shunt infections in children

Clinic and economic results of the ventriculoperitoneal shunt infections in children

Few Patient, Treatment, and Diagnostic or Microbiological Factors, Except Complications and Intermittent Negative Cerebrospinal Fluid (CSF) Cultures During First CSF Shunt Infection, Are Associated With Reinfection

Prevalence and antibiogram of methicillin resistant Staphylococcus aureus isolated from medical device-related infections; a retrospective study in Lahore, Pakistan

Contact Info

Product

Resources

About