2021
DOI: 10.1212/nxi.0000000000000941
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CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS

Abstract: ObjectiveTo identify biomarkers associated with progressive phases of MS and with neuroprotective potential.MethodsCombined analysis of the transcriptional and proteomic profiles obtained in CNS tissue during chronic progressive phases of experimental autoimmune encephalomyelitis (EAE) with the transcriptional profile obtained during the differentiation of murine neural stem cells into neurons. Candidate biomarkers were measured by ELISA in the CSF of 65 patients with MS (29 with relapsing-remitting MS [RRMS],… Show more

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Cited by 21 publications
(29 citation statements)
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References 44 publications
(44 reference statements)
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“…Our results indicate that A2M might be of clinical interest even in earlier stages of pathogenesis [ 44 , 45 ]. Elevated SERPINA3 has been studied for many years due to its connection with neurological diseases such as Alzheimer’s, glioblastoma and multiple sclerosis [ 46 , 47 ]. Recently, it was shown that enhanced SERPINA3 levels result in a poor prognosis for HCC patients due to enhanced transcriptional activity of the hnRNP-K complex [ 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…Our results indicate that A2M might be of clinical interest even in earlier stages of pathogenesis [ 44 , 45 ]. Elevated SERPINA3 has been studied for many years due to its connection with neurological diseases such as Alzheimer’s, glioblastoma and multiple sclerosis [ 46 , 47 ]. Recently, it was shown that enhanced SERPINA3 levels result in a poor prognosis for HCC patients due to enhanced transcriptional activity of the hnRNP-K complex [ 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…Serpins are a family of serine (or cysteine) protease inhibitors involved in several biological functions including homeostasis control [ 73 ]. In the muscle, both Serpinf1 and Serping1 are involved in muscle growth and function through regulation of Akt and FoxO signaling pathways [ 74 76 ] whereas Serpina3n , which has been linked with increased immune response activity, is upregulated in aging astrocytes throughout the brain [ 77 ], as well as in a Prion disease mouse model [ 78 ], and has been implicated in Alzheimer’s disease (AD) [addressed in 79] and in Multiple Sclerosis (MS) disease progression [ 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…Of interest, we found that ICH patients exhibited elevated plasma Serpina3 levels compared with the controls, and the increased level of SERPINA3N in plasma of ICH patients was highly associated with poorer outcome (mRS score 4-6). It has been previously reported that SERPINA3 was identified as a potential diagnostic biomarker in other neurological disorders, such as multiple sclerosis and Alzheimer's disease [ 53 , 54 ]. In fact, after ICH onset, peripheral lymphocytes could be soon activated and subsequently infiltrated into the brain parenchymalocal, accompanied by the release of massive cytokines, chemokines, and proteases [ 55 ], which might prompt the rapid and persistent secretion of Serpina3n to regulate the balance of the immune system.…”
Section: Discussionmentioning
confidence: 99%