CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease
Aurore Delvenne,
Johan Gobom,
Suzanne E. Schindler
et al.
Abstract:INTRODUCTIONWe aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and hippocampal volume (HCV), in Alzheimer's disease (AD) using cerebrospinal fluid (CSF) proteomics.METHODSIndividuals without dementia were classified as A+ (CSF amyloid beta [Aβ]42), T+ (CSF phosphorylated tau181), and N+ or N− based on Ng, NfL, or HCV separately. CSF proteomics were generated and compared between groups using analysis of covariance.RESULTSOnly a f… Show more
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