CSF –Neurofilament correlates with outcome after aneurysmal subarachnoid hemorrhage

Nylén, Karin; Csajbok, L. Z.; Öst, Martin; Rashid, Anas; Karlsson, Jan‐Erik; Blennow, Kaj; Nellgård, Bengt; Rosengren, Lars

doi:10.1016/j.neulet.2006.05.029

Cited by 72 publications

(62 citation statements)

References 15 publications

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“…From a subgroup of the patients, cerebrospinal fluid was analyzed as previously described. 8 The very first status of the patients, before any interventions, was graded according to the World Federation of Neurological Surgeons subarachnoid hemorrhage scale (WFNS), based on records from the local hospitals in the catchment area. The WFNS is a universal grading scale, combining information about the level of consciousness and major focal deficits (aphasia and/or hemiparesis) on 2 different axes.…”

Section: Methodsmentioning

confidence: 99%

Serum Glial Fibrillary Acidic Protein Is Related to Focal Brain Injury and Outcome After Aneurysmal Subarachnoid Hemorrhage

Nylén

Csajbok

Öst

et al. 2007

Stroke

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Background and Purpose— Aneurysmal subarachnoid hemorrhage (aSAH) stands out from other subtypes of stroke because of the high early mortality and the risk of complications. Serum glial fibrillary acidic protein (s-GFAP) concentrations are increased after stroke. The aim of this study was to investigate whether s-GFAP could be used as a marker of brain damage and outcome after aSAH. Methods— Serum samples were obtained on a regular basis from 116 adults during a 2-week period after aSAH and analyzed using an enzyme-linked immunosorbent assay. The World Federation of Neurological Surgeons scale was used for neurological evaluation. Outcome was assessed after 1 year and categorized according to the Extended Glasgow Outcome Scale. Results— Increased s-GFAP levels were seen in 81 of the 116 patients. Maximum s-GFAP correlated with World Federation of Neurological Surgeons scale on arrival and on days 10 to 15 ( r =0.37, P <0.001 and r =0.47, P <0.001, respectively). Furthermore, maximum s-GFAP levels were increased in the patient group with radiological signs of focal lesions acute or at 1 year, compared with the group without focal lesions ( P <0.001 in both comparisons). Patients with secondary events (re-bleeding or ischemia) reached maximum levels later in the series and both maximum and final s-GFAP levels increased compared with the levels in patients without secondary events ( P <0.001 in all 3 comparisons). Finally, maximum s-GFAP correlated with outcome ( r =−0.48, P <0.001) and s-GFAP was an independent predictor of dichotomized outcome. Conclusions— s-GFAP provides information about brain injury severity and outcome after aSAH, which can be useful as a complement to clinical data.

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Section: Methodsmentioning

confidence: 99%

Serum Glial Fibrillary Acidic Protein Is Related to Focal Brain Injury and Outcome After Aneurysmal Subarachnoid Hemorrhage

Nylén

Csajbok

Öst

et al. 2007

Stroke

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“…Data on GFAP levels in ischaemic stroke (Martinez-Morillo et al, 2014;Foerch et al, 2006Foerch et al, , 2012Dvorak et al, 2009;Sellner et al, 2011), subarachnoid haemorrhage (SAH) (Martinez-Morillo et al, 2014;Petzold et al, 2006;Vos et al, 2006;Nylen et al, 2006a;Kaneda et al, 2010), cerebral vasculitis (Nylen et al, 2002) and intracranial haemorrhage ( Data from the ICH studies suggest that blood GFAP levels may be b r a i n r e s e a r c h 1 6 0 0 ( 2 0 1 5 ) 1 7 -3 1 of diagnostic value if taken within 1-6 h after onset of ICH (Foerch et al, 2006(Foerch et al, , 2012Dvorak et al, 2009;Sun et al, 2013;Zhang et al, 2013). Likewise, longitudinal data from SAH indicates a wash-out time of 7-10 days for CSF GFAP levels (Petzold et al, 2006).…”

Section: Cerebrovascular Pathologymentioning

confidence: 99%

Glial fibrillary acidic protein is a body fluid biomarker for glial pathology in human disease

Petzold

2015

Brain Research

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This review on the role of glial fibrillary acidic protein (GFAP) as a biomarker for astroglial pathology in neurological diseases provides background to protein synthesis, assembly, function and degeneration. Qualitative and quantitative analytical techniques for the investigation of human tissue and biological fluid samples are discussed including partial lack of parallelism and multiplexing capabilities. Pathological implications are reviewed in view of immunocytochemical, cell-culture and genetic findings. Particular emphasis is given to neurodegeneration related to autoimmune astrocytopathies and to genetic gain of function mutations. The current literature on body fluid levels of GFAP in human disease is summarised and illustrated by disease specific meta-analyses. In addition to the role of GFAP as a diagnostic biomarker for chronic disease, there are important data on the prognostic value for acute conditions. The published evidence permits to classify the dominant GFAP signatures in biological fluids. This classification may serve as a template for supporting diagnostic criteria of autoimmune astrocytopathies, monitoring disease progression in toxic gain of function mutations, clinical treatment trials (secondary outcome and toxicity biomarker) and provide prognostic information in neurocritical care if used within well defined time-frames.

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“…The phosphorylated forms of NF-H are resistant to proteases and are particularly concentrated in larger diameter axons [1]. It has been reported that NF-L or NF-H in CSF is increased in neurological diseases, including multiple sclerosis, hydrocephalus, subarachnoid hemorrhage, brain damage after cardiac arrest, AIDS dementia complex, Parkinsonian syndromes, amyotrophic lateral sclerosis, and Guillain-Barré syndrome [2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Serial cerebrospinal fluid neurofilament concentrations in bacterial meningitis

Matsushige¹,

Ichiyama²,

Kajimoto³

et al. 2009

Journal of the Neurological Sciences

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CSF –Neurofilament correlates with outcome after aneurysmal subarachnoid hemorrhage

Cited by 72 publications

References 15 publications

Serum Glial Fibrillary Acidic Protein Is Related to Focal Brain Injury and Outcome After Aneurysmal Subarachnoid Hemorrhage

Serum Glial Fibrillary Acidic Protein Is Related to Focal Brain Injury and Outcome After Aneurysmal Subarachnoid Hemorrhage

Glial fibrillary acidic protein is a body fluid biomarker for glial pathology in human disease

Serial cerebrospinal fluid neurofilament concentrations in bacterial meningitis

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