CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving?

Petrakis, Ismene L.; Trevisan, Louis; D’Souza, Cyril; Gil, Roberto; Krasnicki, Susan; Webb, Elizabeth; Heninger, George R.; Cooney, Ned L.; Krystal, John H.

doi:10.1111/j.1530-0277.1999.tb04355.x

Cited by 19 publications

(15 citation statements)

References 45 publications

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“…These findings are in accordance with the results of one other study on plasma HVA in abstinent alcoholics (Fulton et al, 1995), whereas studies on alcoholism examining CSF HVA instead of plasma HVA produced inconsistent results (Heinz et al, 1999;Petrakis et al, 1999;Lappalainen et al, 1999;Virkkunen et al, 1996), most likely caused by the difficulties of determining central HVA concentrations through HVA in CSF.…”

Section: Discussionsupporting

confidence: 81%

“…In contrast to HVA in the cerebrospinal fluid (CSF-HVA) plasma HVA is a potential indicator of central dopaminergic neuronal activity (Amin et al, 1992) and can therefore be used as a tool to study the psychopathology of addictive disorders. So far only few studies have tried to elucidate the role of HVA in human alcoholism with contradictory results (Heinz et al, 1999;Gabel, 1995;Petrakis et al, 1999;Lappalainen et al, 1999;Fulton et al, 1995;Virkkunen et al, 1996). Fulton et al (1995) could show in a case control study with a sufficiently large study population that plasma HVA was significantly lower in alcoholic patients (n ¼ 83) compared to 69 healthy controls.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Köhnke¹,

Wiatr²,

Kolb³

et al. 2002

Neuropsychopharmacol

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The central dopamine system seems to influence addictive disorders. Plasma homovanillic acid (HVA) is an indicator of central dopaminergic activity. In this study the hypothesis that plasma HVA is associated with alcoholism or with delirium tremens (DT) during alcohol withdrawal was tested. A functional genetic polymorphism of the enzyme catechol-O-methyltransferase (COMT) that participates in converting dopamine into its final metabolite HVA was investigated for an association with alcoholism or DT during alcohol withdrawal. In addition, a relation between the functional polymorphism of COMT and plasma HVA concentrations was studied. Plasma HVA concentrations and COMT genotypes were determined in 142 German alcoholics and 101 German healthy controls. Alcoholic patients were examined after a minimum of 3 weeks after cessation of drinking. Mean plasma HVA concentrations were significantly lower in alcoholic patients compared to healthy controls. A group of alcoholics with a history of DT during alcohol withdrawal (n ¼ 62) did not differ significantly in plasma HVA concentrations from alcoholics with a history of only mild withdrawal symptoms (n ¼ 67). The functional polymorphism of the human COMT gene was neither significantly associated with the diagnosis of alcoholism or DT during alcohol withdrawal nor with plasma HVA concentrations.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Köhnke¹,

Wiatr²,

Kolb³

et al. 2002

Neuropsychopharmacol

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“…Our findings are consistent with previous reports that alcoholism affects CSF HVA levels (Roos and Silfverskiöld, 1973;Kato et al, 1979;Goldman et al, 1992;Takahashi et al, 1974;Major et al, 1977;Fujimoto et al, 1983;Roy et al, 1991a;Virkkunen et al, 1996;Fils-Aime et al, 1996;Petrakis et al, 1999). Roy et al (1991a) reported that depressed subjects with alcoholism had significantly lower concentrations of HVA than never depressed subjects with alcoholism.…”

Section: Biological Findingssupporting

confidence: 83%

“…Low CSF HVA may have more to do with psychopathology related to alcoholism as opposed to mood disorder biology. Our finding is consistent with studies that suggest that dopaminergic mechanisms play a part in the biology of alcohol use disorders, including mechanisms of alcohol dependence and withdrawal (Diana et al, 1993;Weiss et al, 1996;Weiss and Koob, 1991;Koob, 1992;Noble, 1996;Wiesbeck et al, 2000;Fromme and D'Amico, 1999;Nevo and Hamon, 1995;Roos and Silfverskiöld, 1973;Kato et al, 1979;Goldman et al, 1992;Takahashi et al, 1974;Major et al, 1977;Fujimoto et al, 1983;Roy et al, 1991a;Virkkunen et al, 1996;Fils-Aime et al, 1996;Petrakis et al, 1999;Samson et al, 1990;Valenzuela and Harris, 1997;Robinson and Berridge, 1993;VavrousekJakuba et al, 1992;Quarfordt et al, 1991;Modell et al, 1993;Grace, 2000).…”

Section: Biological Findingssupporting

confidence: 79%

“…Roy et al (1991a) found lower CSF levels of the dopamine metabolite HVA in depressed compared with never depressed subjects with alcohol dependence. Although multiple studies have shown changes in CSF monoamine metabolites in subjects with alcoholism (Roos and Silfverskiöld, 1973;Kato et al, 1979;Goldman et al, 1992;Takahashi et al, 1974;Major et al, 1977;Fujimoto et al, 1983;Virkkunen et al, 1996;Fils-Aime et al, 1996;Petrakis et al, 1999;Adinoff et al, 1996Adinoff et al, , 1995Adinoff et al, , 1991Geracioti et al, 1994Geracioti et al, , 1993Virkkunen et al, 1994;Kaakkola et al, 1993;Roy et al, 1990;Roy and Linnoila, 1989;Hawley et al, 1988;Borg et al, 1982;Geracioti, 1997), the study by Roy et al (1991a), to our knowledge, is the only study that measured CSF HVA in depressed individuals with alcoholism. Most studies do not distinguish possible biological effects of related psychopathology such as depression, psychosis, suicidal behavior, or smoking.…”

Section: Introductionmentioning

confidence: 99%

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Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

Sher

Oquendo

et al. 2003

Neuropsychopharmacol

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Major depression and alcoholism are often comorbid, resulting in more impairment and more suicidal behavior compared with either diagnosis alone. This study compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with and without a history of alcoholism and healthy volunteers. We hypothesized that depressed subjects with a history of alcoholism would be more aggressive, impulsive, and suicidal than depressed subjects without a history of alcoholism, and would have lower CSF monoamine metabolite levels. We compared 63 subjects with a current major depressive episode (MDE) and a history of alcoholism, 72 subjects with a current MDE but without a history of alcoholism, and 22 healthy volunteers. Participants with a history of alcoholism were in remission for at least 6 months. All subjects were free from prescribed medications known to affect brain serotonin, dopamine, or norepinephrine systems for a minimum of 14 days. Depressive symptoms, lifetime aggression, impulsivity, Axis II disorders, and suicidal behavior were assessed. CSF was sampled and homovanillic acid (HVA), 5-hydroxyindolacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) were assayed by high-performance lipid chromatography with electrochemical detection. Depressed subjects with a history of alcoholism did not differ from depressed subjects without a history of alcoholism in current severity of depressive symptoms, or in past suicidal behavior. Depressed subjects with a history of alcoholism had lower CSF HVA levels, and higher lifetime aggression and current suicide ideation scale scores and were more likely to be tobacco smokers compared with depressed subjects without a history of alcoholism. Low HVA was present after adjustment for sex, aggression and depression scores, cigarette smoking, antisocial and borderline personality disorders, psychomotor retardation, and delusions. Controls had CSF HVA levels intermediate between the two depressed groups. We found no group difference in CSF 5-HIAA and MHPG levels. In individuals with current MDE, those with a history of comorbid alcoholism had lower CSF HVA levels compared with those without a history of alcoholism. Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE.

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Central Noradrenergic Interactions with Alcohol and Regulation of Alcohol-Related Behaviors

Vazey

Hartog

Moorman

2018

Handbook of Experimental Pharmacology

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Alcohol use disorder (AUD) results from disruption of a number of neural systems underlying motivation, emotion, and cognition. Patients with AUD exhibit not only elevated motivation for alcohol but heightened stress and anxiety, and disruptions in cognitive domains such as decision-making. One system at the intersection of these functions is the central norepinephrine (NE) system. This catecholaminergic neuromodulator, produced by several brainstem nuclei, plays profound roles in a wide range of behaviors and functions, including arousal, attention, and other aspects of cognition, motivation, emotional regulation, and control over basic physiological processes. It has been known for some time that NE has an impact on alcohol seeking and use, but the mechanisms of its influence are still being revealed. This chapter will discuss the influence of NE neuron activation and NE release at alcohol-relevant targets on behaviors and disruptions underlying alcohol motivation and AUD. Potential NE-based pharmacotherapies for AUD treatment will also be discussed. Given the basic properties of NE function, the strong relationship between NE and alcohol use, and the effectiveness of current NE-related treatments, the studies presented here indicate an encouraging direction for the development of precise and efficacious future therapies for AUD.

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CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving?

Abstract: These results are inconclusive about the role of monoaminergic dysregulation in recovering alcoholics. They also question the utility of these CSF measures to predict alcohol cue reactivity in patients who have been sober at least 1 month.

Cited by 19 publications

References 45 publications

Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Plasma Homovanillic Acid: A Significant Association with Alcoholism is Independent of a Functional Polymorphism of the Human Catechol-O-Methyltransferase Gene

Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

Central Noradrenergic Interactions with Alcohol and Regulation of Alcohol-Related Behaviors

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