CSF miR-16 expression and its association with miR-16 and serotonin transporter in the raphe of a rat model of depression

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

“…( Table 2) and silence its expression in humans and animals (Baudry et al, 2010;Moya et al, 2013;Song et al, 2015;Shao et al, 2018). The relationship between miR-16 and SERT is even modulated by pharmacological antidepressant treatment and also alternative treatments as the electroacupuncture; besides different responses according to the affected brain area, these treatments improve the level of depressive behaviors, suggesting a highly specific regulation (Baudry et al, 2010;Zhao et al, 2019).…”

“…In the case of depression, it is currently accepted that several miRNAs modulate the activity of the serotonergic system, but little is known about these regulators in the context of eating behavior. As far as we know, miR-16 is able to bind the SERT messenger ( Table 2 ) and silence its expression in humans and animals ( Baudry et al, 2010 ; Moya et al, 2013 ; Song et al, 2015 ; Shao et al, 2018 ). The relationship between miR-16 and SERT is even modulated by pharmacological antidepressant treatment and also alternative treatments as the electroacupuncture; besides different responses according to the affected brain area, these treatments improve the level of depressive behaviors, suggesting a highly specific regulation ( Baudry et al, 2010 ; Zhao et al, 2019 ).…”

Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression

“…Additionally, it was revealed that miR-16 participates in three of these ceRNA regulations, namely MEG8-ITGBL1, MEG8-KCNG3 and MEG8-ACSS2. miR-16 expression is associated with major depression (35–37) and has therefore been used as a serum biomarker for depression (38). This indicates that the lncRNA MEG8 may be a novel molecule implicated in the pathogenesis of depression.…”

Inhibition of miR-16 enhances the sensitivity of fibroblast-like synovial cells to methotrexate by restraining MDR1/P-gp expressionviaNF-κB pathway

“… 24 In a rat model of depression, reflecting raphe miR-16 level, cerebrospinal fluid miR-16 was involved in the pathogenesis of depression and regulated raphe serotonin transporter expression. 25 MiR-16 regulated myoblast proliferation and apoptosis by targeting SESN1, and thus contributed to myoblast differentiation. 26 Some reports have described that miR-16 was also involved in the regulation of drug resistance in diseases.…”