CSF biomarkers in posterior cortical atrophy

Seguin, J.; Formaglio, Maïté; Perret‐Liaudet, Armand; Quadrio, Isabelle; Tholance, Yannick; Rouaud, Olivier; Thomas‐Antérion, Catherine; Croisile, Bernard; Mollion, Hélène; Moreaud, Olivier; Salzmann, Martina; Dorey, Aline; Bataillard, M; Coste, Marie-Hélène; Vighetto, Alain; Krolak‐Salmon, Pierre

doi:10.1212/wnl.0b013e31821ccc98

Cited by 73 publications

(59 citation statements)

References 34 publications

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“…The pathological background of PCA is heterogeneous and the major cause is AD, but also cortico-basal degeneration, prion disease, or four-repeat tauopathy have been identified. Recently, in vivo pathological studies with amyloid PET [16] or CSF biomarkers [17] have been useful in understanding the precise diagnosis of PCA. At the same time, because PCA is a clinical syndrome, clearly identifiable symptoms are essential to its treatment.…”

Section: Discussionmentioning

confidence: 99%

Picture Agnosia as a Characteristic of Posterior Cortical Atrophy

et al. 2012

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Background: Posterior cortical atrophy (PCA) is a degenerative disease characterized by progressive visual agnosia with posterior cerebral atrophy. We examine the role of the picture naming test and make a number of suggestions with regard to diagnosing PCA as atypical dementia. Methods: We investigated 3 cases of early-stage PCA with 7 control cases of Alzheimer disease (AD). The patients and controls underwent a naming test with real objects and colored photographs of familiar objects. We then compared rates of correct answers. Results: Patients with early-stage PCA showed significant inability to recognize photographs compared to real objects (F = 196.284, p = 0.0000) as measured by analysis of variants. This difficulty was also significant to AD controls (F = 58.717, p = 0.0000). Conclusion: Picture agnosia is a characteristic symptom of early-stage PCA, and the picture naming test is useful for the diagnosis of PCA as atypical dementia at an early stage.

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Section: Discussionmentioning

confidence: 99%

Picture Agnosia as a Characteristic of Posterior Cortical Atrophy

et al. 2012

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“…The association of elevated T-tau and P-tau and reduced Ab42 with AD neuropathology has been validated in autopsy [57] and brain biopsy [54] studies. Interestingly, the alterations in CSF Ab42, T-tau, and P-tau are similar between normal AD, where the cognitive dysfunction is dominated by episodic memory loss, and a rarer variant of AD (posterior cortical atrophy), where visuospatial dysfunction dominates [95,96], but this topic has been less thoroughly explored in other clinical variants of AD, including AD presenting with logopenic primary progressive aphasia [97] or corticobasal syndrome [98].…”

Section: Diagnostic Performance Of Combined Csf T-tau P-tau and Ab4mentioning

confidence: 99%

CSF in Alzheimer's Disease

Zetterberg

Lautner

Skillbäck

et al. 2014

Advances in Clinical Chemistry

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“…Given that the majority of subjects with PCA have AD pathophysiology in clinicopathologic series [3][4][5][6][7] and that most subjects with PCA in antemortem studies display CSF biomarker profiles 8,9 and amyloid brain 8,10,11 consistent with those in AD, it is perhaps not surprising that there are genetic risk factors that are shared between LOAD vs PCA and posterior AD. It is entirely possible that LOAD GWAS include subjects that may qualify for early clinical or pathologic diagnosis of PCA or posterior AD, respectively.…”

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confidence: 99%

Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD

et al. 2014

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Objective: To investigate association of genetic risk factors for late-onset Alzheimer disease (LOAD) with risk of posterior cortical atrophy (PCA), a syndrome of visual impairment with predominant Alzheimer disease (AD) pathology in posterior cortical regions, and with risk of "posterior AD" neuropathology. Methods:We assessed 81 participants with PCA diagnosed clinically and 54 with neuropathologic diagnosis of posterior AD vs 2,523 controls for association with 11 significant single nucleotide polymorphisms (SNPs) from published LOAD risk genome-wide association studies.Results: There was highly significant association with APOE e4 and increased risk of PCA (p 5 0.0003, odds ratio [OR] 5 3.17) and posterior AD (p 5 1.11 3 10 217 , OR 5 6.43). No other locus was significant after corrections for multiple testing, although rs11136000 near CLU (p 5 0.019, OR 5 0.60) and rs744373 near BIN1 (p 5 0.025, OR 5 1. 63) associated nominally significantly with posterior AD, and rs3851179 at the PICALM locus had significant association with PCA (p 5 0.0003, OR 5 2.84). ABCA7 locus SNP rs3764650, which was also tested under the recessive model because of Hardy-Weinberg disequilibrium, also had nominally significant association with PCA risk. The direction of association at APOE, CLU, and BIN1 loci was the same for participants with PCA and posterior AD. The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk. Conclusions:We identified a significant effect for APOE and nominate CLU, BIN1, and ABCA7 as additional risk loci for PCA and posterior AD. Our findings suggest that at least some of the genetic risk factors for LOAD are shared with these atypical conditions and provide effect-size estimates for their future genetic studies. Neurology ® 2014;82:1455-1462 GLOSSARY AD 5 Alzheimer disease; BA 5 Brodmann area; CI 5 confidence interval; GWAS 5 genome-wide association study; LOAD 5 late-onset Alzheimer disease; MAF 5 minor allele frequency; NFT 5 neurofibrillary tangle; OR 5 odds ratio; PCA 5 posterior cortical atrophy; SNP 5 single nucleotide polymorphism.

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CSF biomarkers in posterior cortical atrophy

Cited by 73 publications

References 34 publications

Picture Agnosia as a Characteristic of Posterior Cortical Atrophy

Picture Agnosia as a Characteristic of Posterior Cortical Atrophy

CSF in Alzheimer's Disease

Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD

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