CSF‐amine metabolites in depression, dementia and in controls

Gjerris, Annette; Werdelin, L.; Gjerris, F.; Sørensen, P. Soelberg; Rafaelsen, Ole J.; Alling, Christer

doi:10.1111/j.1600-0447.1987.tb02846.x

Cited by 33 publications

(12 citation statements)

References 45 publications

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“…The concentrations of neurotransmitter metabolites in the cerebrospinal fluid (CSF) have been investigated in depression (8,9), but not, to our knowledge, in the hypothyroid state before and after treatment with thyroxine.…”

Section: Introductionmentioning

confidence: 99%

L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study

Sjöberg

Eriksson

Nordin

1998

European Journal of Endocrinology

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Monoamine precursors, neurotransmitters and their metabolites were studied in cerebrospinal fluid (CSF) obtained from nine newly diagnosed hypothyroid patients.Before treatment, the serum TSH correlated positively with the CSF concentrations of tyrosine and phenylalanine.During treatment, the levels of the precursors tryptophan, phenylalanine and tyrosine decreased significantly, as was also the case with dopamine and the noradrenaline metabolite 4-hydroxy-3-methoxyphenylglycol (HMPG), but not with serotonin, noradrenaline and the serotonin metabolite 5-hydroxyindoleacetic acid, nor the dopamine metabolites homovanilic acid and dihydroxyphenylacetic acid. The study provided some indication that the CSF levels of phenylalanine and tyrosine are related to thyroid function. Furthermore, we have found an indication that L-thyroxine treatment affects the CSF levels of the precursors as well as dopamine and HMPG. Our results support the notion that there is an interaction between thyroid function and CSF disposition of monoamine compounds.

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Section: Introductionmentioning

confidence: 99%

L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study

Sjöberg

Eriksson

Nordin

1998

European Journal of Endocrinology

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“…Concentration gradients for HVA and 5-HIAA in successive samples of lumbar CSF have been shown previously (Johansson and Roos, 1975;Sj6str6m et al, 1975;Jakupcevik et al, 1977;Andersen et al, 1981;Bertilsson et al, 1982;Stanley et al, 1985). Cisternal/ventricular and lumbar concentrations of HVA and 5-HIAA have also been compared in some studies, and higher levels of HVA (5-I0 times) and 5-HIAA (3-4 times) in cisternal/ventricular than in lumbar CSF were found (Johansson and Roos, 1975;Gjerris et al, 1987;Degrell and Nagy, 1990). The existence of marked concentration gradients for HVA and 5-HIAA suggests that lumbar CSF-HVA and 5-HIAA levels reflect mainly the dopamine and serotonin metabolism in the brain.…”

Section: Resultsmentioning

confidence: 85%

“…1). A concentration gradient for HMPG in successive samples of lumbar CSF has previously been found in some studies (Ziegler et al, 1977;Andersen et al, 1981;Bertilsson et al, 1982), while other studies have found no difference between ventricular and lumbar CSF levels of HMPG (Gjerris et al, 1987). The reason for the absence of a concentration gradient for HMPG has been suggested to be that a major part of lumbar CSF-HMPG originates from the spinal cord (Post et al, 1973;Wood, 1980;Scheinin, 1985).…”

Section: Resultsmentioning

confidence: 87%

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Concentration gradients for monoamine metabolites in lumbar cerebrospinal fluid

Blennow

Wallin

Gottfries

et al. 1993

J Neural Transm Gen Sect

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Concentration gradients in lumbar cerebrospinal fluid (CSF) for the monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxyphenylglycol (HMPG) were studied in 9 healthy controls and 47 neuropsychiatric patients without diseases causing disturbed CSF circulation. In a serial sampling of the first 24 ml of CSF, steep concentration gradients between the first (0-4th ml) and last (21st-24th ml) portions of CSF were found for HVA (99 +/- 59% increase; p < 0.001) and 5-HIAA (88 +/- 54% increase; p < 0.001), while the concentration gradient was slight for HMPG (11 +/- 7% increase; p < 0.001). The existence of marked concentration gradients for the monoamine metabolites HVA and 5-HIAA gives further evidence for an active transport system for these metabolites and indicates that the lumbar CSF-HVA and 5-HIAA levels reflect the dopamine and serotonin metabolism in the brain. Moreover, the existence of pronounced concentration gradients for HVA and 5-HIAA stresses the importance of making analyses on a standardized volume of CSF.

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“…Maraia et al 14, Curzon et al 5 and Gjerris et al 8 did not find any correlation between CSF-HVA or 5-HIAA measured at the lumbar level and in the lateral ventricles. This together with the reversed ventriculo-lumbar gradients of CSF-DA compared with the gradient for HVA indicate that the ratio between concentrations of the parent amine and the metabolite measured in lumbar CSF cannot be used as a measure for amine turnover.…”

Section: Discussionmentioning

confidence: 96%

Do concentrations of neurotransmitters measured in lumbar cerebrospinal fluid reflect the concentrations at brain level?

Gjerris

Sørensen

et al. 1988

Acta neurochir

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CSF concentrations of vasoactive intestinal polypeptide (VIP), cholecystokinin (CCK), noradrenaline (NA) and dopamine (DA) were measured in the lateral ventricles and at the lumbar level in patients with normal pressure hydrocephalus (NPH). The concentrations of VIP (n = 15), NA (n = 10) and DA (n = 10) were significantly higher at the lumbar level than at the ventricular level, whereas the concentrations of CCK (n = 9) were similar at the two sites. A significant positive correlation between the concentrations measured at the two levels was found for VIP (rs = 0.65; p less than or equal to 0.01) and DA (rs = 0.94; p less than or equal to 0.001). The results indicate that the concentrations of transmitter substances measured in CSF at the lumbar level not necessarily are indicative for concentrations measured more centrally. The negative correlations between Evans ratio and L-CSF VIP (rs = -0.76; p less than or equal to 0.001), and between resistance to outflow and V-CSF as well as L-CSF CCK (rs = -0.75); p less than or equal to 0.05) might be explained by a reduction in number of cortical neurons or by disturbances in CSF dynamics in patients with NPH.

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CSF‐amine metabolites in depression, dementia and in controls

Cited by 33 publications

References 45 publications

L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study

L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study

Concentration gradients for monoamine metabolites in lumbar cerebrospinal fluid

Do concentrations of neurotransmitters measured in lumbar cerebrospinal fluid reflect the concentrations at brain level?

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