CSF 5-HIAA levels are lower in impulsive as compared to nonimpulsive violent suicide attempters and control subjects

Cremniter, D.; Jamain, S; Kollenbach, K.; Alvarez, Jean‐Claude; Lecrubier, Y.; Gilton, A.; Jullien, P.; Lesieur, Philippe; Bonnet, Francis; Spreux‐Varoquaux, Odile

doi:10.1016/s0006-3223(98)00382-5

Cited by 69 publications

(39 citation statements)

References 51 publications

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“…In humans, lower levels of serotonin and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) have been found in impulsive violence compared to premeditated violence [27] and impulsive suicide attempters when compared to non-impulsive suicide attempters [30], [31] [32]. These results are reflected in findings with primates, where lower levels of CSF 5-HIAA have been found in relation to impulsive aggression [33], social impulsivity [34] and impulsive "risk taking" behaviour [33], [35], [36].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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Impulsivity is a trait related to inhibitory control which is expressed in a range of behaviours. Impulsive individuals show a decreased ability to tolerate delay of reinforcement, and more impulsive behaviour has been linked to decreased levels of serotonin and dopamine in a number of species. In domestic dogs, impulsivity is implicated in problem behaviours that result from a lack of self control, but currently there are no published studies that assess behavioural and physiological measures of impulsivity in relation to this trait. Impulsivity scores were calculated for 41 dogs using an owner-report assessment, the Dog Impulsivity Assessment Scale (DIAS).Twenty-three of these subjects completed an operant choice task based on a delayed reward paradigm, to assess their tolerance to delay of reinforcement. High Pressure Liquid Chromatography (HPLC) with Fluorometric Detection was used to detect levels of the metabolites of serotonin (5-HIAA) and dopamine (HVA) in the urine of 17 of the subjects. Higher impulsivity scores were found to be significantly correlated with more impulsive behaviour (reduced tolerance to delay of reinforcement) in the behaviour tests and lower levels of urinary 5-HIAA and 5-HIAA/HVA ratio. The results demonstrate convergent validity between impulsivity (as assessed by the DIAS) and behavioural and physiological parameters.

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Section: Accepted M Manuscriptmentioning

confidence: 99%

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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“…There is no clear-cut relationship between depression itself and levels of 5-HIAA in the CSF (Åsberg, 1997;Feldman et al, 1997, p. 843), although antidepressant drugs themselves tend to lower CSF 5-HIAA (see Bäckman, Alling, Alsén, Regnéll, and Träskman-Bendz (2000)). However, there is a consistent association between low CSF 5-HIAA and suicidal behaviour-not only in depression, but also in schizophrenia and other disorders (seeÅsberg (1997), Cooper, Kelly, and King (1992), Cremniter et al (1999), Träskman-Bendz,Åsberg, and Schalling (1986)). Patients who are prone to suicide, many of whom are depressed, show high impulsivity (Apter, Plutchik, & van Praag, 1993;Corruble, Benyamina, Bayle, Falissard, & Hardy, 2003;Plutchik & Van Praag, 1989).…”

Section: Serotonin (5-ht)mentioning

confidence: 99%

Neural systems implicated in delayed and probabilistic reinforcement

2006

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This review considers the theoretical problems facing agents that must learn and choose on the basis of reward or reinforcement that is uncertain or delayed, in implicit or procedural (stimulus-response) representational systems and in explicit or declarative (action-outcome-value) representational systems. Individual differences in sensitivity to delays and uncertainty may contribute to impulsivity and risk taking. Learning and choice with delayed and uncertain reinforcement are related but in some cases dissociable processes. The contributions to delay and uncertainty discounting of neuromodulators including serotonin, dopamine, and noradrenaline, and of specific neural structures including the nucleus accumbens core, nucleus accumbens shell, orbitofrontal cortex, basolateral amygdala, anterior cingulate cortex, medial prefrontal (prelimbic/infralimbic) cortex, insula, subthalamic nucleus, and hippocampus are examined.

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“…We [26][27][28] and others 24,[29][30][31][32][33] have shown that behavioral dysregulation reflected in impulsive aggression and related traits may be an endophenotype because it has been linked to increased risk for SBs and to the activity and variation of the serotonergic system. Anxiousness, neuroticism and internalizing behaviors have also been linked to serotonergic variants as well as to MDs.…”

Section: Introductionmentioning

confidence: 99%

Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study

et al. 2009

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To investigate similarities and differences in the serotonergic diathesis for mood disorders and suicide attempts, we conducted a study in a cohort followed longitudinally for 22 years. A total of 1255 members of this cohort, which is representative of the French-speaking population of Quebec, were investigated. Main outcome measures included (1) mood disorders (bipolar disorder and major depression) and suicide attempts by early adulthood; (2) odds ratios and probabilities associated with 143 single nucleotide polymorphisms in 11 serotonergic genes, acting directly or as moderators in gene-environment interactions with childhood sexual or childhood physical abuse (CPA), and in gene-gene interactions; (3) regression coefficients for putative endophenotypes for mood disorders (childhood anxiousness) and suicide attempts (childhood disruptiveness). Five genes showed significant adjusted effects (HTR2A, TPH1, HTR5A, SLC6A4 and HTR1A). Of these, HTR2A variation influenced both suicide attempts and mood disorders, although through different mechanisms. In suicide attempts, HTR2A variants (rs6561333, rs7997012 and rs1885884) were involved through interactions with histories of sexual and physical abuse whereas in mood disorders through one main effect (rs9316235). In terms of phenotype-specific contributions, TPH1 variation (rs10488683) was relevant only in the diathesis for suicide attempts. Three genes contributed exclusively to mood disorders, one through a main effect (HTR5A (rs1657268)) and two through gene-environment interactions with CPA (HTR1A (rs878567) and SLC6A4 (rs3794808)). Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders, nor did childhood disruptiveness mediate the effects of TPH1 on suicide attempts. Of the serotonergic genes implicated in mood disorders and suicidal behaviors, four exhibited phenotype-specific effects, suggesting that despite their high concordance and common genetic determinants, suicide attempts and mood disorders may also have partially independent etiological pathways. To identify where these pathways diverge, we need to understand the differential, phenotype-specific gene-environment interactions such as the ones observed in the present study, using suitably powered samples.

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CSF 5-HIAA levels are lower in impulsive as compared to nonimpulsive violent suicide attempters and control subjects

Cited by 69 publications

References 51 publications

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Neural systems implicated in delayed and probabilistic reinforcement

Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study

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